Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata

被引：37
|
作者：
Zhu, Feng [1 ,2 ]
Di, Ying-Tong [1 ]
Liu, Ling-Li [1 ]
Zhang, Qiang [1 ]
Fang, Xin [1 ]
Yang, Ting-Quan [1 ]
Hao, Xiao-Jiang [1 ]
He, Hong-Ping [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 02期
关键词：
ALKALOIDS;
D O I：
10.1021/np900309p
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC50 value of 15.2 mu M.
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页码：233 / 236
页数：4
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