Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata

被引：37

作者：

Zhu, Feng ^{[1
,2
]}

Di, Ying-Tong ^{[1
]}

Liu, Ling-Li ^{[1
]}

Zhang, Qiang ^{[1
]}

Fang, Xin ^{[1
]}

Yang, Ting-Quan ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

He, Hong-Ping ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 02期

关键词：

ALKALOIDS;

D O I：

10.1021/np900309p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC50 value of 15.2 mu M.

引用

页码：233 / 236

页数：4

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