Effect of Formulation Parameters on the Preparation of Superporous Hydrogel Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Carvedilol

被引：14
|
作者：
Mahmoud, Enas Ahmed [1 ]
Bendas, Ehab R. [1 ]
Mohamed, Magdy I. [1 ]
机构：
[1] Cairo Univ, Fac Pharm, Cairo, Egypt
来源：
AAPS PHARMSCITECH | 2010年 / 11卷 / 01期
关键词：
carvedilol; self-nanoemulsifying drug delivery system; superporous hydrogel;
D O I：
10.1208/s12249-009-9359-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
引用
收藏
页码：221 / 225
页数：5
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