Effect of Formulation Parameters on the Preparation of Superporous Hydrogel Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Carvedilol

被引：14
|
作者：
Mahmoud, Enas Ahmed [1 ]
Bendas, Ehab R. [1 ]
Mohamed, Magdy I. [1 ]
机构：
[1] Cairo Univ, Fac Pharm, Cairo, Egypt
来源：
AAPS PHARMSCITECH | 2010年 / 11卷 / 01期
关键词：
carvedilol; self-nanoemulsifying drug delivery system; superporous hydrogel;
D O I：
10.1208/s12249-009-9359-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
引用
收藏
页码：221 / 225
页数：5
相关论文
共 50 条
  • [21] Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS)
    Ashfaq, Mehran
    Shah, Shahid
    Rasul, Akhtar
    Hanif, Muhammad
    Khan, Hafeez Ullah
    Khames, Ahmed
    Abdelgawad, Mohamed A.
    Ghoneim, Mohammed M.
    Ali, Muhammad Yasir
    Abourehab, Mohammad A. S.
    Maheen, Safirah
    Iqbal, Omeira
    Abbas, Ghulam
    El Sisi, Amani M.
    PHARMACEUTICS, 2022, 14 (03)
  • [22] Formulation and evaluation of luteolin supersaturatable self-nanoemulsifying drug delivery system (S-SNEDDS) for enhanced oral bioavailability
    Zhang, Nan
    Zhang, Fei
    Xu, Shuo
    Yun, Kaiqing
    Wu, Wenjing
    Pan, Weisan
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 58
  • [23] Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat flavonoids
    Zhao, Zhijuan
    Cui, Xiaodong
    Ma, Xiaoli
    Wang, Zhuanhua
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 52 (11) : 1265 - 1273
  • [24] Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Apremilast: In Vitro Evaluation and Pharmacokinetics Studies
    Abushal, Ahad S.
    Aleanizy, Fadilah S.
    Alqahtani, Fulwah Y.
    Shakeel, Faiyaz
    Iqbal, Muzaffar
    Haq, Nazrul
    Alsarra, Ibrahim A.
    MOLECULES, 2022, 27 (10):
  • [25] Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs I. Formulation development
    Rao, Sri Priya Venkata Ramana
    Shao, Jun
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 362 (1-2) : 2 - 9
  • [26] Resveratrol loaded self-nanoemulsifying drug delivery system (SNEDDS) for pancreatic cancer: Formulation design, optimization and in vitro evaluation
    Md, Shadab
    Alhakamy, Nabil A.
    Aldawsari, Hibah M.
    Ahmad, Javed
    Alharbi, Waleed S.
    Asfour, Hani Z.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 64
  • [27] Improved antimicrobial activity and oral bioavailability of delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)
    Anwer, Md Khalid
    Iqbal, Muzaffar
    Aldawsari, Mohammed F.
    Alalaiwe, Ahmed
    Ahmed, Mohammed Muqtader
    Muharram, Magdy M.
    Ezzeldin, Essam
    Mahmoud, Mohamed A.
    Imam, Faisal
    Ali, Raisuddin
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 64
  • [28] Development and Characterization of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) of Atorvastatin Calcium
    Mantri, Shiva Kumar
    Pashikanti, Shailaja
    Murthy, V. Ramana
    CURRENT DRUG DELIVERY, 2012, 9 (02) : 182 - 196
  • [29] Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil
    Date, Abhijit A.
    Nagarsenker, M. S.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 329 (1-2) : 166 - 172
  • [30] Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability
    Rasoanirina, Bakoliarisoa Nivomalala Voahangy
    Lassoued, Mohamed Ali
    Kamoun, Amel
    Bahloul, Badr
    Miladi, Karim
    Sfar, Souad
    PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2020, 25 (06) : 694 - 703
12345