Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

被引：23

作者：

Kronenberg, Golo ^{[1
]}

Mosienko, Valentina ^{[2
,4
]}

Gertz, Karen ^{[3
]}

Alenina, Natalia ^{[2
]}

Hellweg, Rainer ^{[1
]}

Klempin, Friederike ^{[2
]}

机构：

[1] Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[2] Max Delbruck Ctr Mol Med MDC, Res Team Cardiovasc Hormones & Peptides, Robert Roessle Str 10, D-13125 Berlin, Germany

[3] Charite, Dept Neurol, D-13353 Berlin, Germany

[4] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2016年 / 266卷 / 03期

关键词：

BDNF; SERT; TPH2; Serotonin; Depression; Antidepressant; MESSENGER-RNA; RAT HIPPOCAMPUS; TRANSPORTER; DEPRESSION; NEUROGENESIS; EXPRESSION; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTRANSMISSION; DEFICIENT; TURNOVER;

D O I：

10.1007/s00406-015-0611-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT-/-) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT-/- mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT-/- mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.

引用

页码：281 / 284

页数：4

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