Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

被引：23
|
作者：
Kronenberg, Golo [1 ]
Mosienko, Valentina [2 ,4 ]
Gertz, Karen [3 ]
Alenina, Natalia [2 ]
Hellweg, Rainer [1 ]
Klempin, Friederike [2 ]
机构：
[1] Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany
[2] Max Delbruck Ctr Mol Med MDC, Res Team Cardiovasc Hormones & Peptides, Robert Roessle Str 10, D-13125 Berlin, Germany
[3] Charite, Dept Neurol, D-13353 Berlin, Germany
[4] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England
来源：
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2016年 / 266卷 / 03期
关键词：
BDNF; SERT; TPH2; Serotonin; Depression; Antidepressant; MESSENGER-RNA; RAT HIPPOCAMPUS; TRANSPORTER; DEPRESSION; NEUROGENESIS; EXPRESSION; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTRANSMISSION; DEFICIENT; TURNOVER;
D O I：
10.1007/s00406-015-0611-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT-/-) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT-/- mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT-/- mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.
引用
收藏
页码：281 / 284
页数：4
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