A NEW TRITERPENE AND A NEW PHLOROGLUCINOL DERIVATIVE FROM THE AERIAL PARTS of Pogostemon auricularius

被引：2

作者：

Duc Viet Ho ^{[1
]}

Linh Thuy Thi Tran ^{[1
,2
]}

Dung Viet Le ^{[2
]}

Hung Manh Tran ^{[3
]}

Nhan Trong Le ^{[1
]}

Anh Tuan Le ^{[4
]}

Hoai Thi Nguyen ^{[1
]}

Raal, Ain ^{[5
]}

机构：

[1] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, 06 Ngo Quyen, Hue City 530000, Vietnam

[2] Natl Inst Med Mat, 3B Quang Trung, Hanoi 100000, Vietnam

[3] Vietnam Natl Univ, Univ Sci, Fac Chem, Med Chem Div, 227 Nguyen Van Cu,Dist 5, Ho Chi Minh City 700000, Vietnam

[4] VAST, Mientrung Inst Sci Res, Quang Tri Ctr Sci & Technol, Dong Ha 520000, Quang Tri, Vietnam

[5] Univ Tartu, Inst Pharm, Fac Med, 1 Nooruse, EE-50411 Tartu, Estonia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 05期

关键词：

Pogostemon auricularius; Lamiaceae; pogostemon; pogostem; cytotoxicity;

D O I：

10.1007/s10600-019-02839-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new triterpene, pogostem (1), and a new phloroglucinol derivative, pogostemon D (2), were isolated from the aerial parts of Pogostemon auricularius (L.) Hassk. Their structures were determined from a combination of 1D NMR, 2D NMR, and HR-ESI-MS. Furthermore, pogostem (1) inhibited the proliferation of five human cancer cell lines, KB, SW-480, AGS, Hep-G2, and LU-1, with IC50 values ranging from 45.92 +/- 5.65 to 65.83 +/- 7.05 mu g/mL.

引用

页码：890 / 894

页数：5

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