Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues

被引：9

作者：

Ung, AT ^{[1
]}

Pyne, SG

Batenburg-Nguyen, U

Davis, AS

Sherif, A

Bischoff, F

Lesage, ASJ

机构：

[1] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[2] Johnson & Johnson Pharmaceut Res & Dev, CNS Discovery Res, Div Janssen Pharmaceut NV, B-2340 Beerse, Belgium

来源：

TETRAHEDRON | 2005年 / 61卷 / 07期

关键词：

D O I：

10.1016/j.tet.2004.12.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conformationally restricted glutamate analogues, 4-aryl-1-amino-2-cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1803 / 1812

页数：10

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