Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues

被引：9
|
作者：
Ung, AT [1 ]
Pyne, SG
Batenburg-Nguyen, U
Davis, AS
Sherif, A
Bischoff, F
Lesage, ASJ
机构：
[1] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia
[2] Johnson & Johnson Pharmaceut Res & Dev, CNS Discovery Res, Div Janssen Pharmaceut NV, B-2340 Beerse, Belgium
来源：
TETRAHEDRON | 2005年 / 61卷 / 07期
关键词：
D O I：
10.1016/j.tet.2004.12.024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The conformationally restricted glutamate analogues, 4-aryl-1-amino-2-cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1803 / 1812
页数：10
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