Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

被引：22
|
作者：
Sakurai, N
Kozuka, M
Tokuda, H
Nobukuni, Y
Takayasu, J
Nishino, H
Kusano, A
Kusano, G
Nagai, M
Sakurai, Y
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Nat Prod Lab, Sch Pharm, Chapel Hill, NC 27599 USA
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
[3] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan
[4] Hoshi Univ, Shinagawa Ku, Tokyo 1428501, Japan
[5] Plantaceut Inc, Res Triangle Pk, NC 27709 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 06期
关键词：
D O I：
10.1016/S0968-0896(02)00432-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1137 / 1140
页数：4
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