Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

被引：31
|
作者：
Itoigawa, M
Ito, C
Wu, TS
Enjo, F
Tokuda, H
Nishino, H
Furukawa, H
机构：
[1] Tokai Gakuen Univ, Miyoshi, Aichi 4700207, Japan
[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 468, Japan
[3] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
CANCER LETTERS | 2003年 / 193卷 / 02期
关键词：
acridone alkaloids; Rutaceous plant; Epstein-Bar virus;
D O I：
10.1016/S0304-3835(03)00008-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Seventeen acridone alkaloids isolated from the Rutaceous plants were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some prenylated acridones were found to have remarkably potent activities. 1,3-Dihydroxy-10-methyl-2,4-diprenylacridone (18) as synthesized according to these results in vitro, exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these acridone alkaloids may be potentially valuable cancer chemopreventive agents. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：133 / 138
页数：6
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