Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

被引：22

作者：

Sakurai, N

Kozuka, M

Tokuda, H

Nobukuni, Y

Takayasu, J

Nishino, H

Kusano, A

Kusano, G

Nagai, M

Sakurai, Y

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Nat Prod Lab, Sch Pharm, Chapel Hill, NC 27599 USA

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[3] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

[4] Hoshi Univ, Shinagawa Ku, Tokyo 1428501, Japan

[5] Plantaceut Inc, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0968-0896(02)00432-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1137 / 1140

页数：4

共 28 条

[21] Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models
Azuine, MA
Tokuda, H
Takayasu, J
Enjyo, F
Mukainaka, T
Konoshima, T
Nishino, H
Kapadia, GJ
PHARMACOLOGICAL RESEARCH, 2004, 49 (02) : 161 - 169
[22] Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis
Colombo, D
Compostella, F
Ronchetti, F
Scala, A
Toma, L
Kuchide, M
Tokuda, H
Nishino, H
CANCER LETTERS, 2000, 161 (02) : 201 - 205
[23] INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS
KONOSHIMA, T
TAKASAKI, M
TATSUMOTO, T
KOZUKA, M
KASAI, R
TANAKA, O
NIE, RL
TOKUDA, H
NISHINO, H
IWASHIMA, A
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1994, 17 (05) : 668 - 671
[24] INHIBITORS OF SKIN-TUMOR PROMOTION .13. INHIBITORY EFFECTS OF EUGLOBALS AND THEIR RELATED-COMPOUNDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND ON 2-STAGE CARCINOGENESIS OF MOUSE SKIN TUMORS .2.
TAKASAKI, M
KONOSHIMA, T
KOZUKA, M
YONEYAMA, K
YOSHIDA, S
TOKUDA, H
NISHINO, H
IWASHIMA, A
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1995, 18 (02) : 288 - 294
[25] INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMOR .2.
KONOSHIMA, T
TAKASAKI, M
KOZUKA, M
NAGAO, T
OKABE, H
IRINO, N
NAKASUMI, T
TOKUDA, H
NISHINO, H
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1995, 18 (02) : 284 - 287
[26] Chemoprevention of Skin Cancer: Effect of Lawsonia inermis L. (Henna) Leaf Powder and its Pigment Artifact, Lawsone in the Epstein- Barr Virus Early Antigen Activation Assay and in Two-Stage Mouse Skin Carcinogenesis Models
Kapadia, Govind J.
Rao, G. Subba
Sridhar, Rajagopalan
Ichiishi, Eiichiro
Takasaki, Midori
Suzuki, Nobutaka
Konoshima, Takao
Iida, Akira
Tokuda, Harukuni
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 13 (10) : 1500 - 1507
[27] Inhibitory effects of dehydrozingerone and related compounds on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation
Motohashi, N
Yamagami, C
Tokuda, H
Konoshima, T
Okuda, Y
Okuda, A
Mukainaka, T
Nishino, H
Saito, Y
CANCER LETTERS, 1998, 134 (01) : 37 - 42
[28] INHIBITORS OF SKIN-TUMOR PROMOTION .8. INHIBITORY EFFECTS OF EUGLOBALS AND THEIR RELATED-COMPOUNDS ON EPSTEIN-BARR-VIRUS ACTIVATION
TAKASAKI, M
KONOSHIMA, T
FUJITANI, K
YOSHIDA, S
NISHIMURA, H
TOKUDA, H
NISHINO, H
IWASHIMA, A
KOZUKA, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (10) : 2737 - 2739

← 1 2 3 →