Correlation Analysis between Central Corneal Thickness and Intraocular Pressure in Juveniles in Northern China: The Jinan City Eye Study

Purpose: To determine the distributions and relation of central corneal thickness (CCT) and intraocular pressure (IOP) by NT-530P in Chinese juveniles, and the effect of gender, age, height, weight and refractive errors on the CTT and IOP. Methods: CCT and IOP of 982 eyes in 514 juveniles aged from 7 to 18 years were measured with NT-530P. Multi-linear regression and ANOVA analysis were used to analyze the relation of CCT and IOP, and the effect of gender, age, height, weight, refractive condition on CCT and IOP respectively. Results: The mean CCT and IOP were 554.19 +/- 35.46 mu m and 15.31 +/- 2.57 mmHg. There were significant correlations between the CCT and IOP values. Linear regression analysis revealed a positive correlation between CCT and IOP (r = 0.44, P<0.05). Linear regression equation: IOP = -2.35+0.032CCT, which means the IOP will increase 0.32 mm Hg for every 10-mu m increase in CCT. The mean of Corrected IOP (CIOP) was 15.32 +/- 2.38 mmHg and had no relation with CCT. There was a negative correlation between refraction degree and CCT (P<0.05), but no correlation between refraction degree and IOP. Multi-linear regression model revealed that the height, weight, age and gender have no effect on the distribution of CCT and IOP respectively. Conclusions: There is a 0.32 mmHg increase in IOP for every 10-mu m increase in CCT. The height, weight, age and gender has no effect on the distribution of CCT and IOP. CCT will become thinner with myopia diopters increases in juveniles. The measurement of CCT is helpful in evaluating the actual IOP correctly.