Pre-clinical proof-of-concept for CAR-T Cells directed against the tumour antigen 5T4 in the treatment of haematological malignancies

被引:0
|
作者
Blount, D. G. [1 ]
Soyombo, M. [1 ]
Moyce, L. [1 ]
Kelleher, M. [1 ]
Harrop, R. [1 ]
机构
[1] Oxford BioMed, Oxford, England
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
P106
引用
收藏
页码:A49 / A49
页数:1
相关论文
共 44 条
  • [1] Pre-clinical development of CAR-T Cells directed against the tumour antigen 5T4 for the treatment of Acute Myeloid Leukaemia
    Blount, D.
    Soyombo, M.
    Moyce, L.
    Khan, N.
    Lobry, T.
    Drayson, M.
    Harrop, R.
    [J]. HUMAN GENE THERAPY, 2021, 32 (19-20) : A92 - A93
  • [2] Pre-Clinical Investigations of CAR T Cells Directed Against the Tumour Antigen 5T4 (OXB-302) in Solid Tumor Models
    Kelleher, Michelle
    Harrop, Richard
    Blount, Daniel
    Gilham, David
    Cheadle, Eleanor
    Edmondson, Richard
    Owens, Gemma
    [J]. MOLECULAR THERAPY, 2019, 27 (04) : 177 - 178
  • [3] The 5T4 tumour associated antigen as a target for CAR-T cell therapy
    Mansbridge, C. T.
    Abdulaziz, M.
    Al-Muftah, Y.
    Stern, P. L.
    Gilham, D.
    [J]. IMMUNOLOGY, 2012, 137 : 723 - 723
  • [4] From clinical proof-of-concept to commercialization of CAR T cells
    Calmels, Boris
    Mfarrej, Bechara
    Chabannon, Christian
    [J]. DRUG DISCOVERY TODAY, 2018, 23 (04) : 758 - 762
  • [5] Chimeric antigen receptor T cells (CAR-T) for the treatment of T-cell malignancies
    Cooper, Mathew L.
    DiPersio, John F.
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2019, 32 (04)
  • [6] Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer.
    Bandara, Veronika
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Coombs, Justin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [7] In-vitro tonic signalling profiling of CAR-T cells generated to support pre-clinical studies for solid tumour targets
    Hunjan, S. S.
    Sampson, R.
    Evans, J.
    Chenoweth, H.
    Garrobo-Calleja, I.
    Lekomtsev, S.
    Zhang, J.
    Zona, S.
    Breuning, J.
    Oren, R.
    Davies, M.
    Di-Tullio, A.
    Euesden, J.
    Kennedy, J.
    Kay, C.
    Colebrook, J.
    Kloke, B. P.
    Southgate, T.
    Lee, J.
    [J]. ANNALS OF ONCOLOGY, 2021, 32 : S371 - S372
  • [8] Real-time cytotoxicity assays as a pre-clinical screening tool for LGR5-targeting CAR-T cells for treatment of solid tumors
    Thompson, Emma J.
    Bandara, Veronika
    Sadlon, Timothy
    Gundsambuu, Batjargal
    Tan, Lih Yin
    Ricciardelli, Carmela
    Barry, Simon C.
    Bonder, Claudine S.
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [9] Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study
    Camilli, Massimiliano
    Viscovo, Marcello
    Felici, Tamara
    Maggio, Luca
    Ballacci, Federico
    Carella, Giacomo
    Bonanni, Alice
    Lamendola, Priscilla
    Tinti, Lorenzo
    Di Renzo, Antonio
    Coarelli, Giulia
    Galli, Eugenio
    Liuzzo, Giovanna
    Burzotta, Francesco
    Montone, Rocco Antonio
    Sora, Federica
    Sica, Simona
    Hohaus, Stefan
    Lanza, Gaetano Antonio
    Crea, Filippo
    Lombardo, Antonella
    Minotti, Giorgio
    [J]. CARDIO-ONCOLOGY, 2024, 10 (01)
  • [10] Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study
    Massimiliano Camilli
    Marcello Viscovo
    Tamara Felici
    Luca Maggio
    Federico Ballacci
    Giacomo Carella
    Alice Bonanni
    Priscilla Lamendola
    Lorenzo Tinti
    Antonio Di Renzo
    Giulia Coarelli
    Eugenio Galli
    Giovanna Liuzzo
    Francesco Burzotta
    Rocco Antonio Montone
    Federica Sorà
    Simona Sica
    Stefan Hohaus
    Gaetano Antonio Lanza
    Filippo Crea
    Antonella Lombardo
    Giorgio Minotti
    [J]. Cardio-Oncology, 10