Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer.

被引:0
|
作者
Bandara, Veronika [1 ]
Mills, Stuart [2 ]
Thompson, Emma [3 ]
Tan, Lih [3 ]
Gundsambuu, Batjargal [1 ]
Napoli, Silvana [1 ]
Foeng, Jade [1 ]
McPeake, Dylan [1 ]
Coombs, Justin [4 ]
Cowin, Allison [2 ]
Bonder, Claudine [3 ]
Sadlon, Timothy [1 ]
McColl, Shaun [4 ]
Barry, Simon [1 ]
机构
[1] Univ Adelaide, North Adelaide, Australia
[2] Univ South Australia, Mawson Lakes, Australia
[3] Univ South Australia, North Adelaide, Australia
[4] Carina Biotech, Adelaide, SA, Australia
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5575
引用
收藏
页数:1
相关论文
共 50 条
  • [1] From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Thompson, Emma
    Mills, Stuart
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    [J]. CANCER RESEARCH, 2024, 84 (06)
  • [2] Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Abbott, Caitlin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon C.
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [3] In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer
    McPeake, Dylan
    Tyllis, Timona
    Abbott, Caitlin
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Rohani-Rad, Elaheh
    Napoli, Silvana
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [4] Assessing LGR5 expression levels on colorectal cancer tissue samples for use in LGR5-targeting CAR-T cell therapy clinical trial
    Thompson, Emma J.
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Foeng, Jade
    McPeake, Dylan
    Tyllis, Timona
    Abbott, Caitlin
    Cowin, Allison
    Sadlon, Timothy
    McColl, Shaun
    Ricciardelli, Carmela
    Barry, Simon C.
    Bonder, Claudine S.
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [5] Real-time cytotoxicity assays as a pre-clinical screening tool for LGR5-targeting CAR-T cells for treatment of solid tumors
    Thompson, Emma J.
    Bandara, Veronika
    Sadlon, Timothy
    Gundsambuu, Batjargal
    Tan, Lih Yin
    Ricciardelli, Carmela
    Barry, Simon C.
    Bonder, Claudine S.
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [6] Preclinical in vivo characterization underpinning LGR5-targeting CAR-T cells as a cancer immunotherapy
    Foeng, Jade
    Tyllis, Timona
    Abbott, Caitlin
    McPeake, Dylan
    Thompson, Emma
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Bonder, Claudine
    Comerford, Iain
    Sadlon, Tim
    Barry, Simon
    McColl, Shaun
    [J]. CANCER RESEARCH, 2024, 84 (06)
  • [7] Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
    Tyllis, Timona
    Abbott, Caitlin
    McPeake, Dylan
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [8] Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
    Veronika Bandara
    Jade Foeng
    Batjargal Gundsambuu
    Todd S. Norton
    Silvana Napoli
    Dylan J. McPeake
    Timona S. Tyllis
    Elaheh Rohani-Rad
    Caitlin Abbott
    Stuart J. Mills
    Lih Y. Tan
    Emma J. Thompson
    Vasiliki M. Willet
    Victoria J. Nikitaras
    Jieren Zheng
    Iain Comerford
    Adam Johnson
    Justin Coombs
    Martin K. Oehler
    Carmela Ricciardelli
    Allison J. Cowin
    Claudine S. Bonder
    Michael Jensen
    Timothy J. Sadlon
    Shaun R. McColl
    Simon C. Barry
    [J]. Nature Communications, 14
  • [9] Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
    Bandara, Veronika
    Foeng, Jade
    Gundsambuu, Batjargal
    Norton, Todd S.
    Napoli, Silvana
    Mcpeake, Dylan J.
    Tyllis, Timona S.
    Rohani-Rad, Elaheh
    Abbott, Caitlin
    Mills, Stuart J.
    Tan, Lih Y.
    Thompson, Emma J.
    Willet, Vasiliki M.
    Nikitaras, Victoria J.
    Zheng, Jieren
    Comerford, Iain
    Johnson, Adam
    Coombs, Justin
    Oehler, Martin K.
    Ricciardelli, Carmela
    Cowin, Allison J.
    Bonder, Claudine S.
    Jensen, Michael
    Sadlon, Timothy J.
    Mccoll, Shaun R.
    Barry, Simon C.
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [10] LGR5 CAR-T cells: A novel potential treatment against high grade serous ovarian cancer.
    Wang, Wanqi
    Bandara, Veronika
    Lokman, Noor
    Napoli, Silvana
    Gundsambuu, Batjargal
    Oehler, Martin
    Barry, Simon C.
    Ricciardelli, Carmela
    [J]. CANCER RESEARCH, 2022, 82 (12)