Assessing LGR5 expression levels on colorectal cancer tissue samples for use in LGR5-targeting CAR-T cell therapy clinical trial

被引:0
|
作者
Thompson, Emma J.
Bandara, Veronika
Gundsambuu, Batjargal
Napoli, Silvana
Mills, Stuart
Foeng, Jade
McPeake, Dylan
Tyllis, Timona
Abbott, Caitlin
Cowin, Allison
Sadlon, Timothy
McColl, Shaun
Ricciardelli, Carmela
Barry, Simon C.
Bonder, Claudine S.
机构
关键词
D O I
10.1158/1538-7445.AM2023-5545
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5545
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer.
    Bandara, Veronika
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Coombs, Justin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    CANCER RESEARCH, 2022, 82 (12)
  • [2] In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer
    McPeake, Dylan
    Tyllis, Timona
    Abbott, Caitlin
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Rohani-Rad, Elaheh
    Napoli, Silvana
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    CANCER RESEARCH, 2023, 83 (07)
  • [3] From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Thompson, Emma
    Mills, Stuart
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    CANCER RESEARCH, 2024, 84 (06)
  • [4] In vivo characterization of a novel CAR-T cell therapy directed towards LGR5 for the treatment of colorectal cancer
    McPeake, Dylan J.
    Tyllis, Timona S.
    Foeng, Jade
    Bandara, Veronika
    Abbott, Caitlin A.
    Gundsambuu, Batjargal
    Rohani-Rad, Elaheh
    Napoli, Silvana
    Sadlon, Timothy
    Barry, Simon C.
    McColl, Shaun R.
    CANCER RESEARCH, 2022, 82 (12)
  • [5] Preclinical in vivo characterization underpinning LGR5-targeting CAR-T cells as a cancer immunotherapy
    Foeng, Jade
    Tyllis, Timona
    Abbott, Caitlin
    McPeake, Dylan
    Thompson, Emma
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Bonder, Claudine
    Comerford, Iain
    Sadlon, Tim
    Barry, Simon
    McColl, Shaun
    CANCER RESEARCH, 2024, 84 (06)
  • [6] CAR-T cells targeting LGR5: An effective treatment for chemotherapy resistant ovarian cancer
    Wang, Wanqi
    Bandara, Veronika
    Lokman, Noor A.
    Price, Zoe K. K.
    Noye, Tannith M.
    Napoli, Silvana
    Gundsambuu, Batjargal
    Oehler, Martin K.
    Barry, Simon C.
    Ricciardelli, Carmela
    CANCER RESEARCH, 2024, 84 (06)
  • [7] Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
    Tyllis, Timona
    Abbott, Caitlin
    McPeake, Dylan
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    CANCER RESEARCH, 2023, 83 (07)
  • [8] EGFR inhibitors increase LGR5 expression and enhance potency of LGR5 antibodydrug conjugates targeting colorectal cancer stem cells
    High, Peyton C.
    Liang, Zhengdong
    Carmon, Kendra S.
    CANCER RESEARCH, 2024, 84 (06)
  • [9] Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Abbott, Caitlin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon C.
    CANCER RESEARCH, 2023, 83 (07)
  • [10] Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
    RG Morgan
    E Mortensson
    AC Williams
    British Journal of Cancer, 2018, 118 : 1410 - 1418