Preclinical in vivo characterization underpinning LGR5-targeting CAR-T cells as a cancer immunotherapy

被引：0
|
作者：
Foeng, Jade
Tyllis, Timona
Abbott, Caitlin
McPeake, Dylan
Thompson, Emma
Bandara, Veronika
Gundsambuu, Batjargal
Napoli, Silvana
Bonder, Claudine
Comerford, Iain
Sadlon, Tim
Barry, Simon
McColl, Shaun
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-56
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
56
引用
收藏
页数：2
相关论文
共 50 条
  • [1] In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer
    McPeake, Dylan
    Tyllis, Timona
    Abbott, Caitlin
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Rohani-Rad, Elaheh
    Napoli, Silvana
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [2] Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer.
    Bandara, Veronika
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Coombs, Justin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [3] From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Thompson, Emma
    Mills, Stuart
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon
    [J]. CANCER RESEARCH, 2024, 84 (06)
  • [4] Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
    Tyllis, Timona
    Abbott, Caitlin
    McPeake, Dylan
    Foeng, Jade
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    Barry, Simon
    McColl, Shaun
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [5] Assessing LGR5 expression levels on colorectal cancer tissue samples for use in LGR5-targeting CAR-T cell therapy clinical trial
    Thompson, Emma J.
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Foeng, Jade
    McPeake, Dylan
    Tyllis, Timona
    Abbott, Caitlin
    Cowin, Allison
    Sadlon, Timothy
    McColl, Shaun
    Ricciardelli, Carmela
    Barry, Simon C.
    Bonder, Claudine S.
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [6] CAR-T cells targeting LGR5: An effective treatment for chemotherapy resistant ovarian cancer
    Wang, Wanqi
    Bandara, Veronika
    Lokman, Noor A.
    Price, Zoe K. K.
    Noye, Tannith M.
    Napoli, Silvana
    Gundsambuu, Batjargal
    Oehler, Martin K.
    Barry, Simon C.
    Ricciardelli, Carmela
    [J]. CANCER RESEARCH, 2024, 84 (06)
  • [7] CAR-T cells for cancer immunotherapy
    Xie, Yangyang
    Li, Xiaotong
    Wu, Jingyi
    Zeng, Huiling
    Boucetta, Hamza
    Wang, Binru
    Yang, Pei
    He, Wei
    [J]. CHINESE CHEMICAL LETTERS, 2023, 34 (09)
  • [8] CAR-T cells for cancer immunotherapy
    Yangyang Xie
    Xiaotong Li
    Jingyi Wu
    Huiling Zeng
    Hamza Boucetta
    Binru Wang
    Pei Yang
    Wei He
    [J]. Chinese Chemical Letters, 2023, 34 (09) : 73 - 82
  • [9] Real-time cytotoxicity assays as a pre-clinical screening tool for LGR5-targeting CAR-T cells for treatment of solid tumors
    Thompson, Emma J.
    Bandara, Veronika
    Sadlon, Timothy
    Gundsambuu, Batjargal
    Tan, Lih Yin
    Ricciardelli, Carmela
    Barry, Simon C.
    Bonder, Claudine S.
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [10] Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
    Bandara, Veronika
    Gundsambuu, Batjargal
    Napoli, Silvana
    Mills, Stuart
    Thompson, Emma
    Tan, Lih
    Foeng, Jade
    McPeake, Dylan
    Tylis, Timona
    Abbott, Caitlin
    Cowin, Allison
    Bonder, Claudine
    Sadlon, Timothy
    McColl, Shaun
    Barry, Simon C.
    [J]. CANCER RESEARCH, 2023, 83 (07)
12345