Exercise-Induced Neuroprotection in the Spastic Han Wistar Rat: The Possible Role of Brain-Derived Neurotrophic Factor

被引:7
|
作者
Van Kummer, Brooke H. [1 ]
Cohen, Randy W. [1 ]
机构
[1] Calif State Univ Northridge, Dept Biol, Northridge, CA 91330 USA
关键词
NERVE GROWTH-FACTOR; PROTEIN-KINASE-C; MESSENGER-RNA; NEURONAL PLASTICITY; BDNF; TRKB; HIPPOCAMPUS; INVOLVEMENT; ACTIVATION; MECHANISMS;
D O I
10.1155/2015/834543
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Moderate aerobic exercise has been shown to enhance motor skills and protect the nervous system from neurodegenerative diseases, like ataxia. Our lab uses the spastic Han Wistar rat as a model of ataxia. Mutant rats develop forelimb tremor and hind limb rigidity and have a decreased lifespan. Our lab has shown that exercise reduced Purkinje cell degeneration and delayed motor dysfunction, significantly increasing lifespan. Our study investigated how moderate exercise may mediate neuroprotection by analyzing brainderived neurotrophic factor (BDNF) and its receptor TrkB. To link BDNF to exercise-induced neuroprotection, mutant and normal rats were infused with the TrkB antagonist K252a or vehicle into the third ventricle. During infusion, rats were subjected to moderate exercise regimens on a treadmill. Exercised mutants receiving K252a exhibited a 21.4% loss in Purkinje cells compared to their controls. Cerebellar TrkB expression was evaluated using non-drug-treated mutants subjected to various treadmill running regimens. Running animals expressed three times more TrkB than sedentary animals. BDNF was quantified via Sandwich ELISA, and cerebellar expression was found to be 26.6% greater in mutant rats on 7-day treadmill exercise regimen compared to 30 days of treadmill exercise. These results suggest that BDNF is involved in mediating exercise-induced neuroprotection.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Exercise-induced Brain-derived neurotrophic factor regulation in the brain dysfunctions
    Rezaee, Z.
    Marandi, S. M.
    Alaei, H.
    Esfarjani, F.
    [J]. SCIENCE & SPORTS, 2023, 38 (5-6) : 519 - 526
  • [2] Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus
    Oliff, HS
    Berchtold, NC
    Isackson, P
    Cotman, CW
    [J]. MOLECULAR BRAIN RESEARCH, 1998, 61 (1-2): : 147 - 153
  • [3] Nutritional strategies for the exercise-induced increases in brain-derived neurotrophic factor
    Decker, Kevin
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2023, 601 (11): : 2217 - 2218
  • [4] Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals
    Pedersen, Bente K.
    Pedersen, Maria
    Krabbe, Karen S.
    Bruunsgaard, Helle
    Matthews, Vance B.
    Febbraio, Mark A.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2009, 94 (12) : 1153 - 1160
  • [5] The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
    Raed AlRuwaili
    Hayder M. Al-kuraishy
    Ali I. Al-Gareeb
    Naif H. Ali
    Athanasios Alexiou
    Marios Papadakis
    Hebatallah M. Saad
    Gaber El-Saber Batiha
    [J]. Neurochemical Research, 2024, 49 : 533 - 547
  • [6] The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
    Alruwaili, Raed
    Al-kuraishy, Hayder M.
    Al-Gareeb, Ali I.
    Ali, Naif H.
    Alexiou, Athanasios
    Papadakis, Marios
    Saad, Hebatallah M.
    Batiha, Gaber El-Saber
    [J]. NEUROCHEMICAL RESEARCH, 2024, 49 (03) : 533 - 547
  • [7] PROGESTERONE, BRAIN-DERIVED NEUROTROPHIC FACTOR AND NEUROPROTECTION
    Singh, M.
    Su, C.
    [J]. NEUROSCIENCE, 2013, 239 : 84 - 91
  • [8] No Influence of Noradrenaline Manipulation on Acute Exercise-Induced Increase of Brain-Derived Neurotrophic Factor
    Goekint, Maaike
    Heyman, Elsa
    Roelands, Bart
    Njemini, Rose
    Bautmans, Ivan
    Mets, Tony
    Meeusen, Romain
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (11): : 1990 - 1996
  • [9] Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain
    Johnson, RA
    Mitchell, GS
    [J]. BRAIN RESEARCH, 2003, 983 (1-2) : 108 - 114
  • [10] Correction to: The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
    Raed AlRuwaili
    Hayder M. Al-kuraishy
    Ali I. Al-Gareeb
    Naif H. Ali
    Athanasios Alexiou
    Marios Papadakis
    Hebatallah M. Saad
    Gaber El-Saber Batiha
    [J]. Neurochemical Research, 2024, 49 (5) : 1417 - 1418