No Influence of Noradrenaline Manipulation on Acute Exercise-Induced Increase of Brain-Derived Neurotrophic Factor

被引:43
|
作者
Goekint, Maaike [1 ,2 ]
Heyman, Elsa [1 ,3 ]
Roelands, Bart [1 ]
Njemini, Rose [4 ,5 ]
Bautmans, Ivan [1 ,4 ,5 ]
Mets, Tony [4 ,5 ]
Meeusen, Romain [1 ]
机构
[1] Vrije Univ Brussels, Fac Phys Educ & Phys Therapy, Dept Human Physiol & Sports Med, B-1050 Brussels, Belgium
[2] Res Fdn, Flanders, Belgium
[3] Univ Lille 2, Fac Sport Sci & Phys Educ, Lab Human Movement Studies, EA3608, F-59800 Lille, France
[4] Vrije Univ Brussels, Fac Med & Pharm, Dept Gerontol, B-1050 Brussels, Belgium
[5] Univ Ziekenhuis Brussel, Dept Geriatr, Brussels, Belgium
来源
关键词
BRAIN-DERIVED NEUROTROPHIC FACTOR; HUMANS; REBOXETINE; SELECTIVE NORADRENALINE REUPTAKE INHIBITOR; COGNITION;
D O I
10.1249/MSS.0b013e31817eee85
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
GOEKINT, M., E. HEYMAN, B. ROELANDS, R. NJEMINI, I. BAUTMANS, T. METS, and R. MEEUSEN. No Influence of Noradrenaline Manipulation oil Acute Exercise-Induced Increase of Brain-Derived Neurotrophic Factor. Med. Sci. Sports Exerc., Vol. 40, No. 11, pp. 1990-1996, 2008. Purpose: To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) oil the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). Methods: In a double-blind, placebo-controlled. crossover design, 11 young, healthy male subjects were treated with either placebo or reboxetine. On each occasion. they performed a 60-min cycling exercise at 55% of their maximal power output followed by a time trial (TT) at 75% of W-max. HR and ratings of perceived exertion were measured. Blood samples were taken at four time points. Results: An increase in serum BDNF was found after exercise without any influence of drug administration oil BDNF levels. Serum BDNF returned to resting levels after 15 min of recovery. Time trial (TT) performance was significantly worse after reboxetine intake. Serum cortisol increased in both trials during and after exercise and was significantly higher in the reboxetine trial. Also, FIR was increased with reboxetine intake, probably because of the sympathomimetic effect of SNRI. Midterm memory was significantly impaired after the exercise protocol without difference between reboxetine and placebo trial. Conclusions: The administration of all SNRI has no effect oil the exercise-induced increase in BDNF. However, effects were seen on serum cortisol. HR. and memory. Future research should focus on the effect of regular exercise training in combination with several reuptake inhibitors in both healthy and depressed subjects on BDNF and memory.
引用
收藏
页码:1990 / 1996
页数:7
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