Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

被引:282
|
作者
Oliff, HS
Berchtold, NC
Isackson, P
Cotman, CW
机构
[1] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Psychobiol, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA
[4] Mayo Clin, Dept Biochem & Mol Biol, Jacksonville, FL 32224 USA
来源
MOLECULAR BRAIN RESEARCH | 1998年 / 61卷 / 1-2期
关键词
brain-derived neurotrophic factor; exon; exercise; rat; hippocampus;
D O I
10.1016/S0169-328X(98)00222-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous results from our laboratory indicate that two nights of voluntary wheel running upregulates brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. In order to investigate the time-course of the BDNF response and to examine how physical activity preferentially activates particular transcriptional pathways, the effects of 6 and 12 h of voluntary wheel running on BDNF and exons I-IV mRNA expression were investigated in rats. Hippocampal full-length BDNF mRNA expression was rapidly influenced by physical activity, showing significant increases in expression levels as soon as 6 h of voluntary wheel running. Moreover, there was a strong positive correlation between distance run and BDNF mRNA expression. Exon I mRNA expression was significantly upregulated after 6 h of running and was maintained or enhanced by 12 h of voluntary running. Exon II had a slower time-course and was significantly upregulated after 12 h, selectively in the CA1 hippocampal region. Exon III and Exon IV showed no significant increase in expression level after 6 or 12 h of running in the paradigm studied. It is significant that the rapid neurotrophin response is demonstrated for a physiologically relevant stimulus, as opposed to the extreme conditions of seizure paradigms. Furthermore, exercise-induced upregulation of BDNF may help increase the brain's resistance to damage and neurodegeneration that occurs with aging. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:147 / 153
页数:7
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