Enantiodivergent total synthesis of trioxilins B3 using Sharpless asymmetric olefin dihydroxylation

被引：4
|
作者：
Lapitskaya, MA [1 ]
Vasiljeva, LL [1 ]
Demin, PM [1 ]
Pivnitsky, KK [1 ]
机构：
[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2004年 / 14卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1070/MC2004v014n06ABEH002003
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The unknown 11, 12-threo-stereoisomers of B-type trioxilins, (10R, 11R, 12S)-TrXB3, its (10S)-epimer and their enantiomers were synthesized (as methyl esters) from a common racemic precursor, viz., methyl rac-10-hydroxyeicos-11 (E)-ene-5,8,14-triynoate, by Sharpless enantiodirected dihydroxylation of the double bond as the key step.
引用
收藏
页码：287 / 290
页数：4
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