Contribution of 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Genotypes to Colorectal Cancer in Taiwan

被引：8

作者：

Wu, Ming-Hsien ^{[1
,2
,3
]}

Chen, Chao-Hsuan ^{[1
,4
,5
]}

Chen, Chou-Pin ^{[6
]}

Huang, Tai-Lin ^{[1
,4
]}

Yueh, Te-Cheng ^{[1
,2
,3
]}

Wang, Zhi-Hong ^{[7
]}

Tsai, Chia-Wen ^{[1
,4
]}

Pei, Jen-Sheng ^{[8
]}

Mong, Mei-Chin ^{[7
]}

Yang, Ya-Chen ^{[7
]}

Bau, Da-Tian ^{[1
,4
,9
]}

Chang, Wen-Shin ^{[4
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Armed Forces Gen Hosp, Div Colon & Rectal Surg, Taichung, Taiwan

[3] Natl Def Med Ctr, Taipei, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan

[5] China Med Univ Hosp, Dept Neurosurg, Taichung, Taiwan

[6] Taichung Vet Gen Hosp, Dept Surg, Taichung, Taiwan

[7] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan

[8] Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Pediat, Taoyuan, Taiwan

[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 05期

关键词：

Colorectal cancer; genotype; MTRR; polymorphism; Taiwan; METHIONINE SYNTHASE REDUCTASE; MTRR GENE POLYMORPHISMS; METALLOPROTEINASE-1; GENOTYPES; PROMOTER GENOTYPES; FOLATE; RISK; MTHFR; DNA; ASSOCIATION; METABOLISM;

D O I：

10.21873/anticanres.15716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. Materials and Methods: A total of 362 cases and 362 controls were recruited and their MTRR rs1801394 (A66G) and rs1532268 (C524T) genotypes were examined. The behavioral factors and clinical pathological factors were also analyzed. Results: MTRR rs1801394 genotypes were associated with CRC risk (p for trend=0.0087). In detail, G/G genotype was associated with lower risk (p=0.0049, OR=0.39, 95%CI=0.20-0.76). As for allelic frequency analysis, G allele was also associated with decreased CRC risk (p=0.0026, OR=0.68, 95%CI=0.53-0.88). There was no significant association as for MTRR rs1532268.

引用

页码：2375 / 2382

页数：8

共 50 条

[41] Contribution of Interleukin-4 Genotypes to Lung Cancer Risk in Taiwan
Chang, Wen-Shin
Wang, Shou-Cheng
Chuang, Chin-Liang
Ji, Hong-Xue
Hsiao, Chieh-Lun
Hsu, Chin-Mu
Tsai, Chia-Wen
Liu, Shih-Ping
Hsu, Pei-Chen
Lo, Yen-Li
Bau, Da-Tian
[J]. ANTICANCER RESEARCH, 2015, 35 (11) : 6297 - 6301
[42] The significant association of CCND1 genotypes with colorectal cancer in Taiwan
Huang, Chung-Yu
Tsai, Chia-Wen
Hsu, Chin-Mu
Chang, Wen-Shin
Shui, Hao-Ai
Bau, Da-Tian
[J]. TUMOR BIOLOGY, 2015, 36 (08) : 6533 - 6540
[43] ESCHERICHIA-COLI-B N5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE COBALAMIN METHYLTRANSFERASE - GEL-FILTRATION BEHAVIOR OF APOENZYME AND HOLOENZYMES
TAYLOR, RT
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 242 (02) : 355 - &
[44] Are the proliferative effects of homocysteine in colon cancer cells reversible after treatment with folate and 5-methyltetrahydrofolate?
Akoglu, B
Caspary, W
[J]. GASTROENTEROLOGY, 2002, 122 (04) : A39 - A39
[45] The contribution of caspase-8 genotypes in the urinary bladder cancer risk in Taiwan
Liao, Cheng-Hsi
Chang, Wen-Shin
Tsai, Chia-Wen
Bau, Da-Tian
Wu, Hsi-Chin
[J]. INTERNATIONAL JOURNAL OF UROLOGY, 2020, 27 : 78 - 78
[46] The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan
Chou, An-Kuo
Hsiao, Chieh-Lun
Shih, Tzu-Ching
Wang, Hwei-Chung
Tsai, Chia-Wen
Chang, Wen-Shin
Liu, Liang-Chih
Way, Tzong-Der
Chung, Jing-Gung
Bau, Da-Tian
[J]. ANTICANCER RESEARCH, 2017, 37 (09) : 4973 - 4977
[47] The contribution of interleukin-8 genotypes and expression to nasopharyngeal cancer susceptibility in Taiwan
Huang, Chung-Yu
Chang, Wen-Shin
Tsai, Chia-Wen
Hsia, Te-Chun
Shen, Te-Chun
Bau, Da-Tian
Shui, Hao-Ai
[J]. MEDICINE, 2018, 97 (36)
[48] PURIFICATION AND CHEMICAL CHARACTERIZATION OF THE VITAMIN-B12-DEPENDENT 5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE METHYLTRANSFERASE FROM ESCHERICHIA-COLI-B
PAESSENS, A
RUDIGER, H
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1980, 112 (01): : 47 - 51
[49] The Significant Impacts of Interleukin-8 Genotypes on the Risk of Colorectal Cancer in Taiwan
Tsai, Chia-Wen
Chang, Wen-Shin
Yueh, Te-Cheng
Wang, Yun-Chi
Chin, Yu-Ting
Yang, Mei-Due
Hung, Yi-Chih
Mong, Mei-Chin
Yang, Ya-Chen
Gu, Jian
Bau, Da-Tian
[J]. CANCERS, 2023, 15 (20)
[50] Impact of Matrix Metalloproteinase-8 Genotypes on Colorectal Cancer Risk in Taiwan
Deng, Yang
Ke, Tao-Wei
Wang, Yun-Chi
Chin, Yu-Ting
Yueh, Te-Cheng
Hung, Yi-Chih
Mong, Mei-Chin
Yang, Ya-Chen
Chang, Wen-Shin
Shen, Te-Chun
Bau, Da-Tian
Tsai, Chia-Wen
[J]. ANTICANCER RESEARCH, 2023, 43 (09) : 3979 - 3985

← 1 2 3 4 5 →