Contribution of 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Genotypes to Colorectal Cancer in Taiwan

被引：8

作者：

Wu, Ming-Hsien ^{[1
,2
,3
]}

Chen, Chao-Hsuan ^{[1
,4
,5
]}

Chen, Chou-Pin ^{[6
]}

Huang, Tai-Lin ^{[1
,4
]}

Yueh, Te-Cheng ^{[1
,2
,3
]}

Wang, Zhi-Hong ^{[7
]}

Tsai, Chia-Wen ^{[1
,4
]}

Pei, Jen-Sheng ^{[8
]}

Mong, Mei-Chin ^{[7
]}

Yang, Ya-Chen ^{[7
]}

Bau, Da-Tian ^{[1
,4
,9
]}

Chang, Wen-Shin ^{[4
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Armed Forces Gen Hosp, Div Colon & Rectal Surg, Taichung, Taiwan

[3] Natl Def Med Ctr, Taipei, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan

[5] China Med Univ Hosp, Dept Neurosurg, Taichung, Taiwan

[6] Taichung Vet Gen Hosp, Dept Surg, Taichung, Taiwan

[7] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan

[8] Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Pediat, Taoyuan, Taiwan

[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 05期

关键词：

Colorectal cancer; genotype; MTRR; polymorphism; Taiwan; METHIONINE SYNTHASE REDUCTASE; MTRR GENE POLYMORPHISMS; METALLOPROTEINASE-1; GENOTYPES; PROMOTER GENOTYPES; FOLATE; RISK; MTHFR; DNA; ASSOCIATION; METABOLISM;

D O I：

10.21873/anticanres.15716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. Materials and Methods: A total of 362 cases and 362 controls were recruited and their MTRR rs1801394 (A66G) and rs1532268 (C524T) genotypes were examined. The behavioral factors and clinical pathological factors were also analyzed. Results: MTRR rs1801394 genotypes were associated with CRC risk (p for trend=0.0087). In detail, G/G genotype was associated with lower risk (p=0.0049, OR=0.39, 95%CI=0.20-0.76). As for allelic frequency analysis, G allele was also associated with decreased CRC risk (p=0.0026, OR=0.68, 95%CI=0.53-0.88). There was no significant association as for MTRR rs1532268.

引用

页码：2375 / 2382

页数：8

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