STAT5 Loss Awakens the Dark Force in Natural Killer Cells

被引：4
|
作者：
Ni, Jing [1 ]
Cerwenka, Adelheid [1 ]
机构：
[1] German Canc Res Ctr, Res Grp Innate Immun, Heidelberg, Germany
来源：
CANCER DISCOVERY | 2016年 / 6卷 / 04期
关键词：
NK CELLS;
D O I：
10.1158/2159-8290.CD-16-0247
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Natural killer cells (NK) are commonly considered to be potent antitumor effector cells. The study by Gotthardt and colleagues challenges this concept and reveals that STAT5-deficient/inhibited NK cells induce angiogenesis and promote tumor progression. These unexpected findings shed new light on potential adverse effects of JAK-STAT inhibitors in the clinics. (C) 2016 AACR.
引用
收藏
页码：347 / 349
页数：3
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