STAT5 Loss Awakens the Dark Force in Natural Killer Cells

被引：4

作者：

Ni, Jing ^{[1
]}

Cerwenka, Adelheid ^{[1
]}

机构：

[1] German Canc Res Ctr, Res Grp Innate Immun, Heidelberg, Germany

来源：

CANCER DISCOVERY | 2016年 / 6卷 / 04期

关键词：

NK CELLS;

D O I：

10.1158/2159-8290.CD-16-0247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer cells (NK) are commonly considered to be potent antitumor effector cells. The study by Gotthardt and colleagues challenges this concept and reveals that STAT5-deficient/inhibited NK cells induce angiogenesis and promote tumor progression. These unexpected findings shed new light on potential adverse effects of JAK-STAT inhibitors in the clinics. (C) 2016 AACR.

引用

页码：347 / 349

页数：3

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