Structure and function of toll-like receptor 8

被引：49
|
作者：
Ohto, Umeharu [1 ]
Tanji, Hiromi [1 ]
Shimizu, Toshiyuki [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] JST, CREST, Tokyo, Japan
来源：
MICROBES AND INFECTION | 2014年 / 16卷 / 04期
关键词：
Toll-like receptor; Innate immunity; Structural biology; SINGLE-STRANDED RNA; LEUCINE-RICH REPEATS; PATHOGEN RECOGNITION; PATTERN-RECOGNITION; CRYSTAL-STRUCTURE; IMMUNE-RESPONSE; CUTTING EDGE; LIPOPOLYSACCHARIDE; ACTIVATION; TLR7;
D O I：
10.1016/j.micinf.2014.01.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：273 / 282
页数：10
相关论文
共 50 条
  • [41] Toll-like receptor signaling
    Akira, S
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) : 38105 - 38108
  • [42] Toll and Toll-like receptor signalling in development
    Anthoney, Niki
    Foldi, Istvan
    Hidalgo, Alicia
    DEVELOPMENT, 2018, 145 (09):
  • [43] Toll-like receptor 7 function is reduced in adolescents with asthma
    Roponen, M.
    Yerkovich, S. T.
    Hollams, E.
    Sly, P. D.
    Holt, P. G.
    Upham, J. W.
    EUROPEAN RESPIRATORY JOURNAL, 2010, 35 (01) : 64 - 71
  • [44] Toll-like receptor expression and function in various cell types
    Renshaw, MA
    Rockwell, J
    Katz, J
    Sambhara, S
    FASEB JOURNAL, 2002, 16 (04): : A321 - A321
  • [45] Development of a clinical assay to evaluate toll-like receptor function
    Deering, RP
    Orange, JS
    CLINICAL AND VACCINE IMMUNOLOGY, 2006, 13 (01) : 68 - 76
  • [46] Toll-like receptor regulation of effector T lymphocyte function
    Reynolds, Joseph M.
    Dong, Chen
    TRENDS IN IMMUNOLOGY, 2013, 34 (10) : 511 - 519
  • [47] Toll-like receptor expression and function in airway epithelial cells
    Greene, CM
    McElvaney, NG
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2005, 53 (05) : 418 - 427
  • [48] Defective toll-like receptor function in common variable immunodeficiency
    Yu, J. E.
    Knight, A. K.
    Radigan, L. R.
    Marron, T.
    Zhang, L.
    Sanchez-Ramon, S.
    Cunningham-Rundles, C.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 154 : 15 - 15
  • [49] Is toll-like receptor 6 or toll-like receptor 10 involved in asthma genetics -: or both?
    Puthothu, B
    Heinzmann, A
    ALLERGY, 2006, 61 (05) : 649 - 650
  • [50] Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease
    Moens, Leen
    Verhaegen, Jan
    Pierik, Marie
    Vermeire, Severine
    De Boeck, Kris
    Peetermans, Willy E.
    Bossuyt, Xavier
    MICROBES AND INFECTION, 2007, 9 (01) : 15 - 20
12345