Structure and function of toll-like receptor 8

被引：49
|
作者：
Ohto, Umeharu [1 ]
Tanji, Hiromi [1 ]
Shimizu, Toshiyuki [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] JST, CREST, Tokyo, Japan
来源：
MICROBES AND INFECTION | 2014年 / 16卷 / 04期
关键词：
Toll-like receptor; Innate immunity; Structural biology; SINGLE-STRANDED RNA; LEUCINE-RICH REPEATS; PATHOGEN RECOGNITION; PATTERN-RECOGNITION; CRYSTAL-STRUCTURE; IMMUNE-RESPONSE; CUTTING EDGE; LIPOPOLYSACCHARIDE; ACTIVATION; TLR7;
D O I：
10.1016/j.micinf.2014.01.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：273 / 282
页数：10
相关论文
共 50 条
  • [21] Toll-like receptor 2 and renal allograft function
    de Groot, Kirsten
    Kuklik, Katharina
    Broecker, Verena
    Schwarz, Anke
    Gwinner, Wilfried
    Kreipe, Hans
    Haller, Hermann
    Fliser, Danilo
    Mengel, Michael
    AMERICAN JOURNAL OF NEPHROLOGY, 2008, 28 (04) : 583 - 588
  • [22] Regulation and function of toll-like receptor 9 in macrophages
    Sweet, Matthew J.
    Schroder, Kate
    Sester, David P.
    Trieu, Angela
    Rehli, Michael
    Risvanathan, Kumar
    Stacey, Katryn J.
    Hume, David A.
    INFLAMMATION RESEARCH, 2005, 54 : S186 - S186
  • [23] JNK inhibition by glucocorticoids prevents the maturation of dendritic cells induced by Toll-like receptor 7 and Toll-like receptor 8
    Larange, Alexandre
    Antonios, Diane
    Pallardy, Marc
    Kerdine-Romer, Saadia
    FASEB JOURNAL, 2008, 22
  • [24] Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists
    Kokatla, Hari Prasad
    Sil, Diptesh
    Tanji, Hiromi
    Ohto, Umeharu
    Malladi, Subbalakshmi S.
    Fox, Lauren M.
    Shimizu, Toshiyoki
    David, Sunil A.
    CHEMMEDCHEM, 2014, 9 (04) : 719 - 723
  • [25] Toll-like receptor 3: A link between toll-like receptor, interferon and viruses
    Matsumoto, M
    Funami, K
    Oshiumi, H
    Seya, T
    MICROBIOLOGY AND IMMUNOLOGY, 2004, 48 (03) : 147 - 154
  • [26] Analysis of Toll-like receptor 7 and Toll-like receptor 9 chimeric molecules
    Willemsen, J.
    Yu, P.
    Bauer, S.
    WIENER KLINISCHE WOCHENSCHRIFT, 2008, 120 : 35 - 35
  • [27] Toll-like receptor 2 and toll-like receptor 4 expression in human adrenals
    Bornstein, SR
    Schumann, RR
    Rettori, V
    McCann, SM
    Zacharowski, K
    HORMONE AND METABOLIC RESEARCH, 2004, 36 (07) : 470 - 473
  • [28] Bovine toll-like receptor 9: A comparative analysis of molecular structure, function and expression
    Griebel, PJ
    Brownlie, R
    Manuja, A
    Nichani, A
    Mookherjee, N
    Popowych, Y
    Mutwiri, G
    Hecker, R
    Babiuk, LA
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2005, 108 (1-2) : 11 - 16
  • [29] Toll-like receptor 8 polymorphisms in Helicobacter pylori infection
    Ferrand, J.
    Hold, G. L.
    Ferrero, R. L.
    El-Omar, E. M.
    Gantier, M.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 637 - 637
  • [30] The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis
    Curtiss, L. K.
    Tobias, P. S.
    CURRENT DRUG TARGETS, 2007, 8 (12) : 1230 - 1238
12345