Structure and function of toll-like receptor 8

被引：49
|
作者：
Ohto, Umeharu [1 ]
Tanji, Hiromi [1 ]
Shimizu, Toshiyuki [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] JST, CREST, Tokyo, Japan
来源：
MICROBES AND INFECTION | 2014年 / 16卷 / 04期
关键词：
Toll-like receptor; Innate immunity; Structural biology; SINGLE-STRANDED RNA; LEUCINE-RICH REPEATS; PATHOGEN RECOGNITION; PATTERN-RECOGNITION; CRYSTAL-STRUCTURE; IMMUNE-RESPONSE; CUTTING EDGE; LIPOPOLYSACCHARIDE; ACTIVATION; TLR7;
D O I：
10.1016/j.micinf.2014.01.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：273 / 282
页数：10
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