Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

被引：24

作者：

Vitorino, Carla ^{[1
,2
,3
]}

Silva, Soraia ^{[1
,2
]}

Bicker, Joana ^{[1
,2
]}

Falcao, Amilcar ^{[1
,2
,4
]}

Fortuna, Ana ^{[1
,2
,4
]}

机构：

[1] Univ Coimbra, Fac Pharm, Coimbra, Portugal

[2] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal

[3] Univ Coimbra, Coimbra Chem Ctr, Dept Chem, Coimbra, Portugal

[4] Univ Coimbra, Coimbra Inst Biomed Imaging & Translat Res, CIBIT ICNAS, Coimbra, Portugal

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 09期

关键词：

DRUG-DELIVERY; INTRANASAL INSULIN; NEUROPEPTIDE-Y; DOUBLE-BLIND; ANXIETY; SYSTEM; NANOPARTICLES; ESKETAMINE; DISORDERS; COGNITION;

D O I：

10.1016/j.drudis.2019.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Why is nose-to-brain delivery considered to be a strategy that directly allows the access of antidepressants to the brain? In which circumstances can the intranasal pathway be applicable? Are there any requirements to follow? What triggers the antidepressant market? Which constraints are imposed during discovery programs? What opportunities can arise and what is their current status of development? Are they already translated into clinical practice? Which challenges are expected from recent development strategies? This review aims at providing a critical appraisal of nose-to-brain delivery of antidepressants, framed within a comprehensive analysis of drivers, restraints, opportunities and challenges.

引用

页码：1911 / 1923

页数：13

共 50 条

[21] Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles
Deepak Sharma
Rakesh Kumar Sharma
Navneet Sharma
Reema Gabrani
Sanjeev K. Sharma
Javed Ali
Shweta Dang
AAPS PharmSciTech, 2015, 16 : 1108 - 1121
[22] Nose-to-Brain delivery of insulin for Alzheimer's disease
Stuetzle, Martina
Flamm, Johannes
Carle, Stefan
Schindowski, Katharina
ADMET AND DMPK, 2015, 3 (03): : 190 - 202
[23] Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols
Alabsi, Wafaa
Eedara, Basanth Babu
Encinas-Basurto, David
Polt, Robin
Mansour, Heidi M.
PHARMACEUTICS, 2022, 14 (09)
[24] Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice
Nicolas Perez-Osorio, Ivan
Espinosa, Alejandro
Giraldo Velazquez, Manuel
Padilla, Patricia
Barcena, Brandon
Fragoso, Gladis
Jung-Cook, Helgi
Besedovsky, Hugo
Meneses, Gabriela
Sciutto Conde, Edda Lydia
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 378 (03): : 244 - 250
[25] Nose-to-brain delivery of insulin enhanced by a nanogel carrier
Picone, Pasquale
Sabatino, Maria Antonietta
Ditta, Lorena Anna
Amato, Antonella
Biagio, Pier Luigi San
Mule, Flavia
Giacomazza, Daniela
Dispenza, Clelia
Di Carlo, Marta
JOURNAL OF CONTROLLED RELEASE, 2018, 270 : 23 - 36
[26] Cachexia: Pathophysiology and Ghrelin Liposomes for Nose-to-Brain Delivery
de Barros, Cecilia T.
Rios, Alessandra C.
Alves, Thais F. R.
Batain, Fernando
Crescencio, Kessi M. M.
Lopes, Laura J.
Zielinska, Aleksandra
Severino, Patricia
Mazzola, Priscila G.
Souto, Eliana B.
Chaud, Marco, V
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) : 1 - 16
[27] Strategies to facilitate or block nose-to-brain drug delivery
Martins, Patricia P.
Smyth, Hugh D. C.
Cui, Zhengrong
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 570
[28] Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles
Ahmad, Ejaj
Feng, Yunhai
Qi, Jianping
Fan, Wufa
Ma, Yuhua
He, Haisheng
Xia, Fei
Dong, Xiaochun
Zhao, Weili
Lu, Yi
Wu, Wei
NANOSCALE, 2017, 9 (03) : 1174 - 1183
[29] On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles
Formica, Maria L.
Real, Daniel A.
Picchio, Matias L.
Catlin, Elise
Donnelly, Ryan F.
Paredes, Alejandro J.
APPLIED MATERIALS TODAY, 2022, 29
[30] Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles
Kuldeep Nigam
Atinderpal Kaur
Amit Tyagi
Md Nematullah
Farah Khan
Reema Gabrani
Shweta Dang
Drug Delivery and Translational Research, 2019, 9 : 879 - 890

← 1 2 3 4 5 →