Endocrine resistance in breast cancer

被引：22

作者：

Zheng, L. H. ^{[1
]}

Zhao, Y. H. ^{[2
]}

Feng, H. L. ^{[2
]}

Liu, Y. J. ^{[1
]}

机构：

[1] Hebei Med Univ, Affiliated Hosp 4, Dept Breast Canc Ctr, Shijiazhuang, Peoples R China

[2] Hebei Med Univ, Affiliated Hosp 4, Dept Orthoped, Shijiazhuang, Peoples R China

来源：

CLIMACTERIC | 2014年 / 17卷 / 05期

关键词：

ENDOCRINE-RESISTANT; BREAST CANCER; ESTROGENS; ACQUIRED-RESISTANCE; ESTROGEN-RECEPTOR; TAMOXIFEN RESISTANCE; MAMMALIAN TARGET; CROSS-TALK; THERAPY; PATHWAY; OVEREXPRESSION; MECHANISMS; EXPRESSION;

D O I：

10.3109/13697137.2013.864268

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Selective estrogen receptor modulators (SERMs) are synthetic molecules which bind to estrogen receptors (ER) and can modulate their transcriptional capabilities in different ways in diverse estrogen target tissues. Unfortunately, the use of resistant therapy is associated with acquired resistance. Several molecular mechanisms have been proposed to be responsible for endocrine resistance in breast cancer, including MIR-451, FGF and FGFR, ADAM12, fibronectin and other soluble stromal factors, PELP1-KDM1, HER2, NOTCH, delta Ef1, mTOR, AKT/mTOR, Pi3K/AKT, Pi3K/AKT/mTOR, NF kappa B, LMTK3, IGF1R, cyclin E2, IRF1, Tab2, and SRC-1. Further research is needed to know more about endocrine resistance.

引用

下载

页码：522 / 528

页数：7

共 50 条

[21] Biological determinants of endocrine resistance in breast cancer
Musgrove, Elizabeth A.
Sutherland, Robert L.
NATURE REVIEWS CANCER, 2009, 9 (09) : 631 - 643
[22] Roles for miRNAs in endocrine resistance in breast cancer
Muluhngwi, Penn
Klinge, Carolyn M.
ENDOCRINE-RELATED CANCER, 2015, 22 (05) : R279 - R300
[23] Endocrine resistance in breast cancer - how to overcome it?
不详
EJC SUPPLEMENTS, 2004, 2 (09): : 41 - 42
[24] Pathways to Endocrine Therapy Resistance in Breast Cancer
Haque, Md Moquitul
Desai, Kartiki, V
FRONTIERS IN ENDOCRINOLOGY, 2019, 10
[25] Overcoming endocrine resistance in neoadjuvant endocrine therapy for early breast cancer
Jackisch, Christian
LANCET ONCOLOGY, 2019, 20 (09): : 1185 - 1187
[26] New insights into acquired endocrine resistance of breast cancer
Fan, Ping
Jordan, V. Craig
CANCER DRUG RESISTANCE, 2019, 2 (02) : 198 - 209
[27] Evolving strategies to overcome endocrine resistance in breast cancer
Hubalek M.
Brunner C.
Marth C.
memo - Magazine of European Medical Oncology, 2012, 5 (2) : 105 - 109
[28] "Braking" the Cycle of Resistance in Endocrine Therapy for Breast Cancer
DeMichele, Angela
Chodosh, Lewis A.
CLINICAL CANCER RESEARCH, 2015, 21 (22) : 4999 - 5001
[29] Predicting response/resistance to endocrine therapy for breast cancer
Miller, WR
Anderson, TJ
Evans, D
Krause, A
Dixon, JM
BREAST CANCER RESEARCH, 2005, 7 (Suppl 2) : S5 - S6
[30] Cannibalism, cell survival, and endocrine resistance in breast cancer
Robert Clarke
Breast Cancer Research, 13

← 1 2 3 4 5 →