Roles for miRNAs in endocrine resistance in breast cancer

被引：70
|
作者：
Muluhngwi, Penn [1 ]
Klinge, Carolyn M. [1 ]
机构：
[1] Univ Louisville, Sch Med, Ctr Genet & Mol Med, Dept Biochem & Mol Genet, Louisville, KY 40292 USA
来源：
ENDOCRINE-RELATED CANCER | 2015年 / 22卷 / 05期
基金：
美国国家卫生研究院;
关键词：
antiestrogen; aromatase inhibitor; breast cancer; endocrine-resistance; estrogen receptor; miRNA; tamoxifen; ESTROGEN-RECEPTOR-ALPHA; NF-KAPPA-B; SIGNAL-TRANSDUCTION INHIBITORS; CONFERS TAMOXIFEN RESISTANCE; EXOSOME-MEDIATED TRANSFER; AROMATASE INHIBITORS; MESSENGER-RNAS; POSTMENOPAUSAL WOMEN; DOWN-REGULATION; UP-REGULATION;
D O I：
10.1530/ERC-15-0355
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Therapies targeting estrogen receptor alpha (ER alpha), including selective ER modulators such as tamoxifen, selective ER downregulators such as fulvestrant (ICI 182 780), and aromatase inhibitors such as letrozole, are successfully used in treating breast cancer patients whose initial tumor expresses ER alpha. Unfortunately, the effectiveness of endocrine therapies is limited by acquired resistance. The role of microRNAs (miRNAs) in the progression of endocrine-resistant breast cancer is of keen interest in developing biomarkers and therapies to counter metastatic disease. This review focuses on miRNAs implicated as disruptors of antiestrogen therapies, their bona fide gene targets and associated pathways promoting endocrine resistance.
引用
收藏
页码：R279 / R300
页数：22
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