A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models

被引：15
|
作者：
Brehmer, Dirk
Wu, Tongfei
Mannens, Geert
Beke, Lijs
Vinken, Petra
Gaffney, Dana
Sun, Weimei
Pande, Vineet
Thuring, Jan-Willem
Millar, Hillary
Poggesi, Italo
Somers, Ivan
Boeckx, An
Parade, Marc
van Heerde, Erika
Nys, Thomas
Yanovich, Carol
Herkert, Barbara
Verhulst, Tinne
Du Jardin, Marc
Meerpoel, Lieven
Moy, Christopher
Diels, Gaston
Viellevoye, Marcel
Schepens, Wim
Poncelet, Alain
Linders, Joannes T.
Lawson, Edward C.
Edwards, James P.
Chetty, Dushen
Laquerre, Sylvie
Lorenzi, Matthew V.
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-DDT02-04
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DDT02-04
引用
收藏
页数：2
相关论文
共 50 条
  • [31] The discovery and preclinical characterization of the SAM-competitive PRMT5 inhibitor UCT-000445
    McDermott, Martina S.
    O'Brien, Neil A.
    O'Boyle, Brendan
    Bartberger, Michael
    Loson, Oliver C.
    Chau, Kevin
    Schwab, Ella
    Hong, Jenny
    Zhou, Jiaying
    Hu, Chuhong
    Luo, Tong
    Ayala, Raul
    Glasby, John
    Stoltz, Brian M.
    Slamon, Dennis J.
    CANCER RESEARCH, 2023, 83 (07)
  • [32] PRMT5 activates KLF5 by methylation to facilitate lung cancer
    Zhou, Hai
    Chang, Jing
    Zhang, Jingjian
    Zheng, Hongzhen
    Miao, Xiang
    Mo, Huimin
    Sun, Jie
    Jia, Qin
    Qi, Guangsheng
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2024, 28 (05)
  • [33] Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity
    Zhang, Meng
    Ding, Xiaoyu
    Cao, Zhongying
    Yang, Yilin
    Ding, Xiao
    Cai, Xin
    Zhang, Man
    Aliper, Alex
    Ren, Feng
    Lu, Hongfu
    Zhavoronkov, Alex
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (02) : 1940 - 1955
  • [34] Inhibition of PRMT5 results in radiosensitization in lung cancer cell lines
    Sharma, Smitha
    Wu, X.
    Smith, P.
    Denko, N.
    Li, C.
    Lai, H.
    Yan, F.
    Shilo, K.
    Chakravarti, A.
    Sif, S.
    Baiocchi, R.
    Otterson, G.
    Xu-Welliver, Meng
    CANCER RESEARCH, 2014, 74 (19)
  • [35] TNG908, a brain-penetrant MTA-cooperative PRMT5 inhibitor, is efficacious in preclinical glioblastoma models
    Zhang, Minjie
    Tsai, Alice
    Cottrell, Kevin M.
    Haines, Brian B.
    Wilker, Erik
    DiBenedetto, Heather
    Weitzman, Ron
    Huang, Alan
    Davis, Charles B.
    Maxwell, John P.
    Briggs, Kimberly J.
    CANCER RESEARCH, 2023, 83 (07)
  • [36] A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer
    Ponath, Paul
    Menezes, Daniel
    Pan, Chin
    Chen, Bing
    Oyasu, Miho
    Strachan, Debbie
    LeBlanc, Heidi
    Sun, Huadong
    Wang, Xi-Tao
    Rangan, Vangipuram S.
    Deshpande, Shrikant
    Cristea, Sandra
    Park, Kwon-Sik
    Sage, Julien
    Cardarelli, Pina M.
    CLINICAL CANCER RESEARCH, 2018, 24 (20) : 5178 - 5189
  • [37] Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue
    Prabhu, Lakshmi
    Martin, Matthew
    Chen, Lan
    Demir, Ozlem
    Jin, Jiamin
    Huang, Xiumei
    Motolani, Aishat
    Sun, Mengyao
    Jiang, Guanglong
    Nakshatri, Harikrishna
    Fishel, Melissa L.
    Sun, Steven
    Safa, Ahmad
    Amaro, Rommie E.
    Kelley, Mark R.
    Liu, Yunlong
    Zhang, Zhong-Yin
    Lu, Tao
    GENES & DISEASES, 2023, 10 (01) : 267 - 283
  • [38] PRMT5 selective inhibitor enhances therapeutic efficacy of cisplatin in lung adenocarcinoma cells
    Bajbouj, Khuloud
    Ramakrishnan, Rakhee
    Ihmaid, Ahmed M. H.
    Ali, Suhaib Al Haj
    Alalool, Abdulla
    Abdullah, Reem
    Saber-Ayad, Maha
    Hamid, Qutayba
    CANCER RESEARCH, 2019, 79 (13)
  • [39] LKB1 regulates PRMT5 activity in breast cancer
    Lattouf, Hanine
    Kassem, Loay
    Jacquemetton, Julien
    Choucair, Ali
    Poulard, Coralie
    Tredan, Olivier
    Corbo, Laura
    Diab-Assaf, Mona
    Hussein, Nader
    Treilleux, Isabelle
    Le Romancer, Muriel
    INTERNATIONAL JOURNAL OF CANCER, 2019, 144 (03) : 595 - 606
  • [40] Novel, small-molecule PRMT5 inhibitors for treatment of cancer
    Sivanandhan, Dhanalakshmi
    Garapaty, Shivani
    Vadivelu, Saravanan
    Seerapu, Guru Pavan Kumar
    Das, Reshma
    Kar, Ronodip
    Singh, Anuj Kumar
    Venkateshappa, Venkatesha Ashokkumar
    Tamizharasan, Natarajan
    Swamy, Indu N.
    Nagaraju, Nagendra
    Kanagaraj, Subramaniyam
    Sarkar, Sayanti
    Tibhe, Jagadish D.
    Rudresh, G.
    Zainuddin, Mohd
    Kandan, Saravanan
    Rajagopal, Sridharan
    Rajagopal, Sriram
    CANCER RESEARCH, 2018, 78 (13)
12345