共 50 条
- [1] Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma[J]. BLOOD, 2014, 124 (21)Penebre, Elayne论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAKuplast, Kristy G.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAMajer, Christina R.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAJohnston, L. Danielle论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USARioux, Nathalie论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAMunchhof, Michael论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAJin, Lei论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USABoriak-Sjodin, P. Ann论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAWigle, Tim J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAJacques, Suzanne L.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAWest, Kip A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USALingaraj, Trupti论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAStickland, Kimberly论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USARibich, Scott A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USARaimondi, Alejandra论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAPorter-Scott, Margaret论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAWaters, Nigel J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAPollock, Roy M.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USASmith, Jesse J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USABarbash, Olena论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Canc Epigenet DPU, Collegeville, PA USA Epizyme Inc, Cambridge, MA USAKruger, Ryan G.论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Collegeville, PA USA Epizyme Inc, Cambridge, MA USACopeland, Robert A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAMoyer, Mikel P.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USAChesworth, Richard论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USADuncan, Kenneth W.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Cambridge, MA USA Epizyme Inc, Cambridge, MA USA
- [2] JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models[J]. CANCER RESEARCH, 2018, 78 (13)Wu, Tongfei论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumMillar, Hillary论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumGaffney, Dana论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumBeke, Lijs论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumMannens, Geert论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumVinken, Petra论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumSommers, Ivan论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumThuring, Jan-Willem论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumSun, Weimei论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumMoy, Christopher论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumPande, Vineet论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, BelgiumZhou, Junguo论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumHaddish-Berhane, Nahor论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumSalvati, Mark论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumLaquerre, Sylvie论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumLorenzi, Matthew V.论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Spring House, PA USA Johnson & Johnson, Beerse, BelgiumBrehmer, Dirk论文数: 0 引用数: 0 h-index: 0机构: Johnson & Johnson, Beerse, Belgium Johnson & Johnson, Beerse, Belgium
- [3] Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity in in vitro and in vivo models[J]. CANCER RESEARCH, 2020, 80 (16)Bhagwat, Neha论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAZhang, Yang论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USALin, Hong论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAWang, Min论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USARominger, Dave论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAEmm, Tom论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAChugani-Mahtani, Divya论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAAngelis, Dimitrios论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAShetty, Rupa论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USALeal, Raul论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAGowen-MacDonald, William论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAGrego, Alexander论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USALuengo, Juan论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAManshouri, Taghi论文数: 0 引用数: 0 h-index: 0机构: Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Prelude Therapeut, Wilmington, DE USAPastore, Friederike论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA Prelude Therapeut, Wilmington, DE USALevine, Ross L.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA Prelude Therapeut, Wilmington, DE USAVerstovsek, Srdan论文数: 0 引用数: 0 h-index: 0机构: Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Prelude Therapeut, Wilmington, DE USARuggeri, Bruce论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAScherle, Peggy论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USAVaddi, Kris论文数: 0 引用数: 0 h-index: 0机构: Prelude Therapeut, Wilmington, DE USA Prelude Therapeut, Wilmington, DE USA
- [4] A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models[J]. NATURE CHEMICAL BIOLOGY, 2015, 11 (06) : 432 - +Chan-Penebre, Elayne论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAKuplast, Kristy G.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAMajer, Christina R.论文数: 0 引用数: 0 h-index: 0机构: Warp Dr Bio, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USABoriack-Sjodin, P. Ann论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAWigle, Tim J.论文数: 0 引用数: 0 h-index: 0机构: Warp Dr Bio, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAJohnston, L. Danielle论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USARioux, Nathalie论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAMunchhof, Michael J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAJin, Lei论文数: 0 引用数: 0 h-index: 0机构: Agile Biostruct Solut, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAJacques, Suzanne L.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAWest, Kip A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USALingaraj, Trupti论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAStickland, Kimberly论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USARibich, Scott A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USARaimondi, Alejandra论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAScott, Margaret Porter论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAWaters, Nigel J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAPollock, Roy M.论文数: 0 引用数: 0 h-index: 0机构: Warp Dr Bio, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USASmith, Jesse J.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USABarbash, Olena论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Canc Epigenet DPU, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAPappalardi, Melissa论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Canc Epigenet DPU, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAHo, Thau F.论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Dept Biol Reagents & Assay Dev, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USANurse, Kelvin论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Dept Biol Reagents & Assay Dev, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAOza, Khyati P.论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Dept Biol Reagents & Assay Dev, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAGallagher, Kathleen T.论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Discovery Core Technol & Capabil, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAKruger, Ryan论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Canc Epigenet DPU, Collegeville, PA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAMoyer, Mikel P.论文数: 0 引用数: 0 h-index: 0机构: Raze Therapeut, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USACopeland, Robert A.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USAChesworth, Richard论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USADuncan, Kenneth W.论文数: 0 引用数: 0 h-index: 0机构: Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA Epizyme Inc, Dept Mol Discovery, Cambridge, MA USA Epizyme Inc, Dept Biol, Cambridge, MA 02139 USA
- [5] A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models[J]. Nature Chemical Biology, 2015, 11 (6) : 432 - 437Chan-Penebre E.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAKuplast K.G.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAMajer C.R.论文数: 0 引用数: 0 h-index: 0机构: Warp Drive Bio, Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MABoriack-Sjodin P.A.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAWigle T.J.论文数: 0 引用数: 0 h-index: 0机构: Warp Drive Bio, Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAJohnston L.D.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MARioux N.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAMunchhof M.J.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAJin L.论文数: 0 引用数: 0 h-index: 0机构: Agile Biostructure Solutions, Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAJacques S.L.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAWest K.A.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MALingaraj T.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAStickland K.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MARibich S.A.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MARaimondi A.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAScott M.P.论文数: 0 引用数: 0 h-index: 0机构: Genentech, San Francisco, CA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAWaters N.J.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAPollock R.M.论文数: 0 引用数: 0 h-index: 0机构: Warp Drive Bio, Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MASmith J.J.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MABarbash O.论文数: 0 引用数: 0 h-index: 0机构: Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAPappalardi M.论文数: 0 引用数: 0 h-index: 0机构: Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAHo T.F.论文数: 0 引用数: 0 h-index: 0机构: Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MANurse K.论文数: 0 引用数: 0 h-index: 0机构: Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAOza K.P.论文数: 0 引用数: 0 h-index: 0机构: Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAGallagher K.T.论文数: 0 引用数: 0 h-index: 0机构: Discovery Core Technologies and Capabilities, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAKruger R.论文数: 0 引用数: 0 h-index: 0机构: Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, PA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAMoyer M.P.论文数: 0 引用数: 0 h-index: 0机构: Raze Therapeutics, Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MACopeland R.A.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MAChesworth R.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MADuncan K.W.论文数: 0 引用数: 0 h-index: 0机构: Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, MA
- [6] In vivo efficacy and pharmacodynamic modulation of JNJ-64619178, a selective PRMT5 inhibitor, in human lung and hematologic preclinical models[J]. CANCER RESEARCH, 2019, 79 (13)Millar, Hillary J.论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USABrehmer, Dirk论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USAVerhulst, Tinne论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USAHaddish-Berhane, Nahor论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USAGreway, Tony论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USAGaffney, Dana论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USABoeckx, An论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USAVan Heerde, Erika论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USANys, Thomas论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USAPortale, Joseph论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USAPhilippar, Ulrike论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USAWu, Tongfei论文数: 0 引用数: 0 h-index: 0机构: Janssen Pharmaceut, Beerse, Belgium Janssen Res & Dev LLC, Spring House, PA USALaquerre, Sylvie论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Spring House, PA USA Janssen Res & Dev LLC, Spring House, PA USAPackman, Kathryn论文数: 0 引用数: 0 h-index: 0机构: Janssen Res & Dev LLC, Cambridge, MA USA Janssen Res & Dev LLC, Spring House, PA USA
- [7] Preclinical In vivo evaluation of efficacy, pharmacokinetics and pharmacodynamics of novel PRMT5 inhibitors in multiple tumor models[J]. CANCER RESEARCH, 2018, 78 (13)Chikkanna, Dinesh论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaPanigrahi, Sunil Kumar论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaRajagopalan, Sujatha论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaSammeta, Srinivasa Raju论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaChawla, Darshan论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaPavithra, S.论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaSamiulla, D. S.论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaPrasanna, Angelene论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaChand, Priyabrata论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaAithal, Kiran论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaMarri, Sai Sudheer论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaKumar, Naveen论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaGanipisetty, Srinivasa Rao论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaMutyala, Raju论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaRao, Kasieswara论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaAntony, Thomas论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaDaginakatte, Girish论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaLakshminarasimhan, Anirudha论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaMohan, R.论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaNarasihmarao, K.论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaChelur, Shekar论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaPandit, Chetan论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaSamajdar, Susanta论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, IndiaRamachandra, Murali论文数: 0 引用数: 0 h-index: 0机构: Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India
- [8] LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity[J]. ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (07): : 612 - 617Bonday, Zahid Q.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USACortez, Guillermo S.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAGrogan, Michael J.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAAntonysamy, Stephen论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAWeichert, Ken论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USABocchinfuso, Wayne P.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA论文数: 引用数: h-index:机构:Kennedy, Steven论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USALi, Binghui论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAMader, Mary M.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAArrowsmith, Cheryl H.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Univ Toronto, Dept Med Biophys, 101 Coll St,MaRS South Tower,Suite 707, Toronto, ON M5G 1L7, Canada Princess Margaret Canc Ctr, 101 Coll St,MaRS South Tower,Suite 707, Toronto, ON M5G 1L7, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA论文数: 引用数: h-index:机构:Eram, Mohammad S.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USASzewczyk, Magdalena M.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USABarsyte-Lovejoy, Dalia论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAVedadi, Masoud论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAGuccione, Ernesto论文数: 0 引用数: 0 h-index: 0机构: Inst Mol & Cell Biol, Singapore 138673, Singapore Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USACampbell, Robert M.论文数: 0 引用数: 0 h-index: 0机构: Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
- [9] Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)Liu, Shuangjie论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R ChinaLiu, Zhuonan论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R ChinaPiao, Chiyuan论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R ChinaZhang, Zhe论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China论文数: 引用数: h-index:机构:Yin, Lei论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R ChinaLiu, Xi论文数: 0 引用数: 0 h-index: 0机构: China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China
- [10] Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity[J]. CANCER RESEARCH, 2018, 78 (13)Mcalpine, Indrawan J.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USATatlock, John论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USABillitti, Joseph论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USABraganza, John论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USABrooun, Alexei论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USADeng Ya-Li论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAHirakawa, Brad论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAJensen-Pergakes, Kristen论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAKumpf, Robert论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USALiu, Wei论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAMaegley, Karen论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAMcTigue, Michele论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAPatman, Ryan论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USARui, Eugene论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAScales, Stephanie论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USASpiegel, Noah论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USATran-Dube, Michelle论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAWang, Fen论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAWang, Zhenxiong论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAYamazaki, Shinji论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAZhang, Tao论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USAWythes, Martin论文数: 0 引用数: 0 h-index: 0机构: Pfizer Global R&D, San Diego, CA USA Pfizer Global R&D, San Diego, CA USA