Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

被引：10

作者：

Fox, Edward J. ^{[1
]}

Salk, Jesse J. ^{[1
,2
]}

Loeb, Lawrence A. ^{[1
,3
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Div Oncol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

GENOME MEDICINE | 2016年 / 8卷

关键词：

Cancer Genome; Driver Mutation; Mutational Signature; Mutation Accumulation; International Cancer Genome Consortium;

D O I：

10.1186/s13073-016-0286-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.

引用

页数：3

共 50 条

[41] Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications
Harris, Reuben S.
GENOME MEDICINE, 2013, 5
[42] Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications
Reuben S Harris
Genome Medicine, 5
[43] Mutational signatures in EGFR sensitizing mutation positive lung adenocarcinoma
Kim, Eun Young
Kim, Arum
Chang, Yoon Soo
CANCER RESEARCH, 2018, 78 (13)
[44] Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Li, Xiangchun
Wu, William K. K.
Xing, Rui
Wong, Sunny H.
Liu, Yuexin
Fang, Xiaodong
Zhang, Yanlin
Wang, Mengyao
Wang, Jiaqian
Li, Lin
Zhou, Yong
Tang, Senwei
Peng, Shaoliang
Qiu, Kunlong
Chen, Longyun
Chen, Kexin
Yang, Huanming
Zhang, Wei
Chan, Matthew T. V.
Lu, Youyong
Sung, Joseph J. Y.
Yu, Jun
CANCER RESEARCH, 2016, 76 (07) : 1724 - 1732
[45] Clinically relevant mutational signatures in childhood cancer
Shlien, Adam
CANCER RESEARCH, 2020, 80 (14) : 25 - 26
[46] Esophageal cancer mutational signatures around the world
Marios Giannakis
Ulrike Peters
Nature Genetics, 2021, 53 : 1522 - 1523
[47] The mutational signatures and molecular alterations of bladder cancer
Ju, Young Seok
TRANSLATIONAL CANCER RESEARCH, 2017, 6 : S689 - S701
[48] Mutational signatures and mutable motifs in cancer genomes
Rogozin, Igor B.
Pavlov, Youri I.
Goncearenco, Alexander
De, Subhajyoti
Lada, Artem G.
Poliakov, Eugenia
Panchenko, Anna R.
Cooper, David N.
BRIEFINGS IN BIOINFORMATICS, 2018, 19 (06) : 1085 - 1101
[49] The Repertoire of Mutational Signatures in Human Cancer.
Alexandrov, L.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2018, 59 : 25 - 25
[50] Application of Mutational Signatures of Carcinogens as Biomarkers of Cancer
Fedeles, Bogdan I.
Essigmann, John M.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2022, 63 : 50 - 50

← 1 2 3 4 5 →