Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

被引：10

作者：

Fox, Edward J. ^{[1
]}

Salk, Jesse J. ^{[1
,2
]}

Loeb, Lawrence A. ^{[1
,3
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Div Oncol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

GENOME MEDICINE | 2016年 / 8卷

关键词：

Cancer Genome; Driver Mutation; Mutational Signature; Mutation Accumulation; International Cancer Genome Consortium;

D O I：

10.1186/s13073-016-0286-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.

引用

页数：3

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