Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase

被引：2
|
作者：
Cheng, Keguang [1 ,2 ]
Wang, Chao [1 ]
Liu, Jun [3 ]
Xie, Juan [2 ]
Sun, Hongbin [1 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, Coll Pharm, Nanjing 210009, Peoples R China
[2] CNRS, ENS Cachan, PPSM, F-94230 Cachan, France
[3] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210009, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Glycogen phosphorylase; Oleanolic acid; C-28; derivatives; Synthesis; Inhibition; PENTACYCLIC TRITERPENES; BIOLOGICAL EVALUATION; ANTIDIABETIC AGENTS; TARGET;
D O I：
10.2174/157018010790225921
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.
引用
收藏
页码：116 / 121
页数：6
相关论文
共 50 条
  • [1] Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase
    Cheng, Keguang
    Liu, Jun
    Liu, Xiaofeng
    Li, Honglin
    Sun, Hongbin
    Xie, Juan
    [J]. CARBOHYDRATE RESEARCH, 2009, 344 (07) : 841 - 850
  • [2] Synthesis of Oleanolic Acid Dimers as Inhibitors of Glycogen Phosphorylase
    Cheng, Keguang
    Liu, Jun
    Sun, Hongbin
    Xie, Juan
    [J]. CHEMISTRY & BIODIVERSITY, 2010, 7 (03) : 690 - 697
  • [3] Synthesis of novel oleanolic acid and ursolic acid in C-28 position derivatives as potential anticancer agents
    Tian, Tian
    Liu, Xinyu
    Lee, Eung-Seok
    Sun, Jingyang
    Feng, Zhonghua
    Zhao, Longxuan
    Zhao, Chunhui
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (04) : 458 - 468
  • [4] Synthesis of novel oleanolic acid and ursolic acid in C-28 position derivatives as potential anticancer agents
    Tian Tian
    Xinyu Liu
    Eung-Seok Lee
    Jingyang Sun
    Zhonghua Feng
    Longxuan Zhao
    Chunhui Zhao
    [J]. Archives of Pharmacal Research, 2017, 40 : 458 - 468
  • [5] Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase
    Chen, J
    Liu, J
    Zhang, LY
    Wu, GZ
    Hua, WY
    Wu, XM
    Sun, HB
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) : 2915 - 2919
  • [6] Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity
    Cheng, Ke-Guang
    Su, Chun-Hua
    Yang, Lin-Dong
    Liu, Jun
    Chen, Zhen-Feng
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 89 : 480 - 489
  • [7] Anticancer activity of oleanolic acid and its derivatives modified at A-ring and C-28 position
    Gao, Cong-Xi
    Tang, Cai-Hong
    Wu, Ting-Juan
    Hu, Yue
    Peng, Ya-Ling
    Liu, Mei-Ling
    Liu, Qian-Wen
    Chen, Hong-Fei
    Yang, Ze-Hua
    Zheng, Xing
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023, 25 (06) : 581 - 594
  • [8] Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives
    Spivak, Anna
    Khalitova, Rezeda
    Nedopekina, Darya
    Dzhemileva, Lilya
    Yunusbaeva, Milyausha
    Odinokov, Victor
    D'yakonov, Vladimir
    Dzhemilev, Usein
    [J]. MOLECULES, 2018, 23 (11):
  • [9] Evaluation of novel Hyphodermin derivatives as Glycogen Phosphorylase a inhibitors
    Loughlin, Wendy A.
    Pierens, Gregory K.
    Petersson, Maria J.
    Henderson, Luke C.
    Healy, Peter C.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (11) : 6172 - 6178
  • [10] Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors
    Wen, XA
    Zhang, P
    Liu, J
    Zhang, LY
    Wu, XM
    Ni, PZ
    Sun, HB
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (03) : 722 - 726
12345