Anticancer activity of oleanolic acid and its derivatives modified at A-ring and C-28 position

被引：7

作者：

Gao, Cong-Xi ^{[1
,2
,3
]}

Tang, Cai-Hong ^{[1
]}

Wu, Ting-Juan ^{[1
]}

Hu, Yue ^{[1
]}

Peng, Ya-Ling ^{[1
]}

Liu, Mei-Ling ^{[1
]}

Liu, Qian-Wen ^{[1
]}

Chen, Hong-Fei ^{[1
]}

Yang, Ze-Hua ^{[1
]}

Zheng, Xing ^{[1
]}

机构：

[1] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Grp Lead Compound,Dept Pharm,Hengyang Med Sch, Hengyang 421001, Peoples R China

[2] Kunming Med Univ, Sch Pharm, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Nat Med Pharmacol, Kunming 650500, Yunnan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 06期

关键词：

Oleanolic acid derivatives; A ring modification; anticancer activity; C-28 site modification; mechanism of action; HEPATOCELLULAR-CARCINOMA CELLS; CANCER CELLS; CYCLE ARREST; IN-VITRO; APOPTOSIS; AUTOPHAGY; DEATH; PROLIFERATION; CYTOTOXICITY; ANGIOGENESIS;

D O I：

10.1080/10286020.2022.2120863

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Oleanolic acid (OA) is a five-ring triterpenoid compound, which is widely present in plants. Due to a wide range of pharmacological activities, oleanolic acid has attracted more and more attention. However, oleanolic acid is insoluble in water and has low bioavailability, which limits its clinical application. In this review, we focus on summarizing the anti-cancer activity and mechanism of the A ring or C-28 carboxyl modified derivatives of OA since 2015, to determine the strength of its anti-cancer effectiveness and evaluate whether it could be used as a clinical anti-cancer drug.

引用

页码：581 / 594

页数：14

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