Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase

被引：2
|
作者：
Cheng, Keguang [1 ,2 ]
Wang, Chao [1 ]
Liu, Jun [3 ]
Xie, Juan [2 ]
Sun, Hongbin [1 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, Coll Pharm, Nanjing 210009, Peoples R China
[2] CNRS, ENS Cachan, PPSM, F-94230 Cachan, France
[3] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210009, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Glycogen phosphorylase; Oleanolic acid; C-28; derivatives; Synthesis; Inhibition; PENTACYCLIC TRITERPENES; BIOLOGICAL EVALUATION; ANTIDIABETIC AGENTS; TARGET;
D O I：
10.2174/157018010790225921
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.
引用
收藏
页码：116 / 121
页数：6
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