Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent

被引：39
|
作者：
Bapat, K
Chintalwar, GJ
Pandey, U
Thakur, VS
Sarma, HD
Samuel, G
Pillai, MRA
Chattopadhyay, S
Venkatesh, M [1 ]
机构：
[1] Bhabha Atom Res Ctr, Radiopharmaceut Div, Bombay 400085, Maharashtra, India
[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
[3] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India
来源：
APPLIED RADIATION AND ISOTOPES | 2005年 / 62卷 / 03期
关键词：
Psoralea corylifolia; I-125-bakuchiol; anti-tumor activity; lymphosarcoma; radiation-induced T-cell lymphoma;
D O I：
10.1016/j.apradiso.2004.07.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, antimicrobial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with I-125. In-vitro uptake studies I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, I-125-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：389 / 393
页数：5
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