Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent

被引：39

作者：

Bapat, K

Chintalwar, GJ

Pandey, U

Thakur, VS

Sarma, HD

Samuel, G

Pillai, MRA

Chattopadhyay, S

Venkatesh, M ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Radiopharmaceut Div, Bombay 400085, Maharashtra, India

[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India

[3] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India

来源：

APPLIED RADIATION AND ISOTOPES | 2005年 / 62卷 / 03期

关键词：

Psoralea corylifolia; I-125-bakuchiol; anti-tumor activity; lymphosarcoma; radiation-induced T-cell lymphoma;

D O I：

10.1016/j.apradiso.2004.07.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, antimicrobial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with I-125. In-vitro uptake studies I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, I-125-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：389 / 393

页数：5

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