Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4

被引：41
|
作者：
Maya, ABS
del Rey, B
de Clairac, RPL
Caballero, E
Barasoain, I
Andreu, JM
Medarde, M
机构：
[1] Univ Salamanca, Fac Farm, Lab Quim Organ & Farmaceut, E-37007 Salamanca, Spain
[2] CSIC, Ctr Invest Biol, E-28006 Madrid, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 22期
关键词：
D O I：
10.1016/S0960-894X(00)00506-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 3,4,5-trimethoxyphenyl and 3-hydroxy-4-methoxyphenyl rings of combretastatin A-4 are deemed optimal for its activity as antimitotic agent. The replacement of either one by a naphthalene ring results in compounds with a potency comparable to that of the parent compound. These results show that the naphthalene ring is a good surrogate for the 3,4,5-trimethoxyphenyl or the 3-hydroxy-4-methoxyphenyl rings of combretastatin A-4 and that neither of them is essential for the antitumor activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2549 / 2551
页数：3
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