Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4

被引：41

作者：

Maya, ABS

del Rey, B

de Clairac, RPL

Caballero, E

Barasoain, I

Andreu, JM

Medarde, M

机构：

[1] Univ Salamanca, Fac Farm, Lab Quim Organ & Farmaceut, E-37007 Salamanca, Spain

[2] CSIC, Ctr Invest Biol, E-28006 Madrid, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(00)00506-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 3,4,5-trimethoxyphenyl and 3-hydroxy-4-methoxyphenyl rings of combretastatin A-4 are deemed optimal for its activity as antimitotic agent. The replacement of either one by a naphthalene ring results in compounds with a potency comparable to that of the parent compound. These results show that the naphthalene ring is a good surrogate for the 3,4,5-trimethoxyphenyl or the 3-hydroxy-4-methoxyphenyl rings of combretastatin A-4 and that neither of them is essential for the antitumor activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2549 / 2551

页数：3

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