Potentiometric determination of pantoprazole using an ion-selective sensor based on polypyrrole doped films

The present work reports for the first time the use of polypyrrole (PPy) doped film for development of a potentiometric disposable sensor for determination of pantoprazole (PTZ), a drug used for ulcer treatment. Selective potentiometric response has been found by using a membrane of PPy doped with PTZ anions prepared under galvanostatic conditions at graphite pencil electrode (GPEM/PPy-PTZ) surface. Potentiometric response has been influenced for conditions adopted in polymerization and measurement step. After optimization of experimental (e.g. pH and time of conditioning) and instrumental parameters (e.g. current density and electrical charge) a linear analytical curve from 1.0 x 10(-5) to 1.1 x 10(-2) mol L-1 with a slope of calibration of the 57.6 mV dec(-1) and limit of detection (LOD) of 6.9 x 10(-6) mol L-1 was obtained. The determination of the PTZ content in pharmaceutical samples using the proposed methodology and official method recommended by Brazilian Pharmacopeia are in agreement at the 95% confidence level and within an acceptable range of error. (C) 2014 Elsevier B.V. All rights reserved.