Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids

被引：4
|
作者：
Dolsak, Ana [1 ]
Mrgole, Kristjan [1 ]
Sova, Matej [1 ]
机构：
[1] Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia
来源：
CATALYSTS | 2021年 / 11卷 / 04期
关键词：
cross-coupling; Suzuki; palladium; pyrimidines; synthesis; microwave-assisted;
D O I：
10.3390/catal11040439
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Suzuki coupling reaction has been often used for the preparation of a diverse set of substituted pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation led to a very efficient and straightforward synthetic procedure providing C4-substituted pyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings.
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页数：16
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