Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

被引:116
|
作者
Liao, XB [1 ]
Wu, YS [1 ]
De Brabander, JK [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
关键词
antitumor agents; configuration determination; cyclization; natural products; total synthesis;
D O I
10.1002/anie.200351145
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:1648 / 1652
页数:5
相关论文
共 50 条
  • [41] Acetylated analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity
    Gunasekera, SP
    Longley, RE
    Isbrucker, RA
    JOURNAL OF NATURAL PRODUCTS, 2001, 64 (02): : 171 - 174
  • [42] Synthetic studies of microtubule stabilizing agent peloruside A:: an asymmetric synthesis of C10-C24 segment
    Ghosh, AK
    Kim, JH
    TETRAHEDRON LETTERS, 2003, 44 (41) : 7659 - 7661
  • [43] Molecular modeling study on the differential microtubule-stabilizing effect in singly- and doubly-bonded complexes with peloruside A and paclitaxel
    Zuniga, Matias A.
    Alderete, Joel B.
    Jana, Gonzalo A.
    Navarrete, Karen R.
    Jimenez, Veronica A.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 87 (08) : 668 - 678
  • [44] Histopathologic changes induced by the microtubule-stabilizing agent taxol in the rat hippocampus in vivo
    Mercado-Gómez, O
    Ferrera, P
    Arias, C
    JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 78 (04) : 553 - 562
  • [45] Design, synthesis and SAR of novel hybrid constructs based on the common pharmacophore for microtubule-stabilizing agents
    Lin, SN
    Inoue, T
    Borella, CP
    Chakravarty, S
    Pera, P
    Bernacki, RJ
    Horwitz, SB
    Ojima, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1166 - U1166
  • [46] Epothilones: A novel class of non-taxane microtubule-stabilizing agents
    Altaha, R
    Fojo, T
    Reed, E
    Abraham, J
    CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (19) : 1707 - 1712
  • [47] Synthetic studies toward the microtubule-stabilizing agent laulimalide:: synthesis of the C15-C28 fragment
    Messenger, BT
    Davidson, BS
    TETRAHEDRON LETTERS, 2001, 42 (05) : 801 - 803
  • [48] Synthetic studies toward the microtubule-stabilizing agent laulimalide:: synthesis of the C1-C14 fragment
    Nadolski, GT
    Davidson, BS
    TETRAHEDRON LETTERS, 2001, 42 (05) : 797 - 800
  • [49] Strategies for the synthesis of the novel antitumor agent peloruside A
    Williams, David R.
    Nag, Partha P.
    Zorn, Nicolas
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2008, 11 (02) : 251 - 271
  • [50] Synthesis of novel, simplified, C-7 substituted eleutheside analogues with potent microtubule-stabilizing activity
    Castoldi, D
    Caggiano, L
    Bayón, P
    Costa, AM
    Cappella, P
    Sharon, O
    Gennari, C
    TETRAHEDRON, 2005, 61 (08) : 2123 - 2139