Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

被引：116
|
作者：
Liao, XB [1 ]
Wu, YS [1 ]
De Brabander, JK [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 14期
关键词：
antitumor agents; configuration determination; cyclization; natural products; total synthesis;
D O I：
10.1002/anie.200351145
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：1648 / 1652
页数：5
相关论文
共 50 条
  • [21] Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A
    Ariane Chan
    A. Jonathan Singh
    Peter T. Northcote
    John H. Miller
    Investigational New Drugs, 2015, 33 : 564 - 574
  • [22] Peloruside A and paclitaxel synergize in their cytotoxic and microtubule-stabilizing effects in cultured cancer cell lines
    Miller, John H.
    Wilmes, Anja
    Bargh, Kelly
    Kelly, Colleen
    Northcote, Peter T.
    CANCER RESEARCH, 2006, 66 (08)
  • [23] A MICROTUBULE-STABILIZING AGENT INHIBITS PROTEOGLYCAN SECRETION IN CHONDROBLASTS
    PACIFICI, M
    TOKUNAKA, S
    SOLTESZ, R
    THAL, G
    SHANLEY, D
    HOLTZER, H
    JOURNAL OF CELL BIOLOGY, 1982, 95 (02): : A399 - A399
  • [24] 4′-Methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent
    Marinho, Joana
    Pedro, Madalena
    Pinto, Diana C. G. A.
    Silva, Artur M. S.
    Cavaleiro, Jose A. S.
    Sunkel, Claudio E.
    Nascimento, Maria Sao Jose
    BIOCHEMICAL PHARMACOLOGY, 2008, 75 (04) : 826 - 835
  • [25] Ixabepilone -: Antimitotic drug, microtubule-stabilizing agent, epothilone
    Mani, Sridhar
    Ghalib, Mohammed
    Goel, Sanjay
    Serradell, N.
    Bolos, J.
    Rosa, E.
    DRUGS OF THE FUTURE, 2007, 32 (12) : 1033 - 1039
  • [26] Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease
    Kanakkanthara, Arun
    Northcote, Peter T.
    Miller, John H.
    NATURAL PRODUCT REPORTS, 2016, 33 (04) : 549 - 561
  • [27] Discodermolide: Just another microtubule-stabilizing agent? No! A lesson in synergy
    Giannakakou, P
    Fojo, T
    CLINICAL CANCER RESEARCH, 2000, 6 (05) : 1613 - 1615
  • [28] Patupilone. Antimitotic drug, microtubule-stabilizing agent, oncolytic
    Larkin, James M. G.
    DRUGS OF THE FUTURE, 2007, 32 (04) : 323 - 336
  • [29] Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents
    Chen, Xiaoyan
    Winstead, Angela
    Yu, Hongtao
    Peng, Jiangnan
    CANCERS, 2021, 13 (04) : 1 - 19
  • [30] Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin
    Paterson, I
    Britton, R
    Delgado, O
    Meyer, A
    Poullennec, KG
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (35) : 4629 - 4633
12345