Charge switch derivatization of phosphopeptides for enhanced surface-enhanced Raman spectroscopy and mass spectrometry detection

被引：7
|
作者：
Li, Handong [1 ]
Sundararajan, Narayan [1 ]
机构：
[1] Intel Corp, Digital Hlth Grp, Santa Clara, CA 95054 USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 08期
关键词：
phosphopeptides; charge switching; beta-elimination; michael addition; phosphonium or ammonium tagged peptides; surface-enhanced Raman spectroscopy (SERS); mass spectrometry;
D O I：
10.1021/pr0606225
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We report an aqueous one-pot reaction chemistry to derivatize phosphopeptides by switching the negatively charged phosphate group to a positively charged phosphonium or ammonium moiety. The phosphonium or ammonium tagged peptides then serve as peptide or protein phosphorylation signatures allowing extended and more sensitive analyses using surface-enhanced Raman spectroscopy (SERS) and mass spectrometry.
引用
收藏
页码：2973 / 2977
页数：5
相关论文
共 50 条
  • [31] Quantitative surface-enhanced Raman spectroscopy
    Bell, Steven E. J.
    Sirimuthu, Narayana M. S.
    CHEMICAL SOCIETY REVIEWS, 2008, 37 (05) : 1012 - 1024
  • [32] Reproducibility in surface-enhanced Raman spectroscopy
    Xiong M.
    Ye J.
    Journal of Shanghai Jiaotong University (Science), 2014, 19 (06) : 681 - 690
  • [33] Surface-enhanced Raman Spectroscopy of Pterins
    Smyth, Ciaran A.
    Mirza, Inam
    Lunney, James G.
    McCabe, Eithne M.
    PLASMONICS IN BIOLOGY AND MEDICINE IX, 2012, 8234
  • [34] Surface-enhanced Raman spectroscopy of DNA
    Barhoumi, Aoune
    Zhang, Dongmao
    Tam, Felicia
    Halas, Naomi J.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (16) : 5523 - 5529
  • [35] Urinalysis by surface-enhanced Raman spectroscopy
    Farquharson, S
    Lee, YH
    Kwon, H
    Shahriari, M
    Rainey, P
    SPACE TECHNOLOGY AND APPLICATIONS INTERNATIONAL FORUM, PTS 1 AND 2, 2000, 504 : 306 - 311
  • [36] Electrochemical surface-enhanced Raman spectroscopy
    Nature Reviews Methods Primers, 3
  • [37] Advances in landmine detection using surface-enhanced Raman spectroscopy
    Spencer, KM
    Sylvia, JM
    Janni, JA
    Klein, JD
    DETECTION AND REMEDIATION TECHNOLOGIES FOR MINES AND MINELIKE TARGETS IV, PTS 1 AND 2, 1999, 3710 : 373 - 379
  • [38] Application advances of surface-enhanced Raman spectroscopy in food detection
    Deng, Sumei
    Liu, Sha
    Kang, Kai
    Li, Guanghua
    Kang, Weijun
    Gao, Zhixian
    Chinese Journal of Analysis Laboratory, 2022, 41 (02) : 232 - 239
  • [39] Quantitative butyrylcholinesterase activity detection by surface-enhanced Raman spectroscopy
    Nechaeva, Natalia
    Prokopkina, Taisiya
    Makhaeva, Galina
    Rudakova, Elena
    Boltneva, Natalia
    Dishovsky, Christophor
    Eremenko, Arkadiy
    Kurochkin, Ilya
    SENSORS AND ACTUATORS B-CHEMICAL, 2018, 259 : 75 - 82
  • [40] Application of Surface-Enhanced Raman Spectroscopy for Foodborne Pathogens Detection
    Wang Xiao-hui
    Xu Tao-tao
    Huang Yi-qun
    Lai Ke-qiang
    Fan Yu-xia
    SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39 (01) : 123 - 129
12345