Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures

被引：29
|
作者：
Yuhas, Y
Weizman, A
Ashkenazi, S
机构：
[1] Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-49181 Petah Tiqwa, Israel
[2] Felsenstein Med Res Ctr, IL-49181 Petah Tiqwa, Israel
[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期
关键词：
D O I：
10.1128/IAI.71.4.2288-2291.2003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was pro-convulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.
引用
收藏
页码：2288 / 2291
页数：4
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