Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures

被引：29
|
作者：
Yuhas, Y
Weizman, A
Ashkenazi, S
机构：
[1] Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-49181 Petah Tiqwa, Israel
[2] Felsenstein Med Res Ctr, IL-49181 Petah Tiqwa, Israel
[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期
关键词：
D O I：
10.1128/IAI.71.4.2288-2291.2003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was pro-convulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.
引用
收藏
页码：2288 / 2291
页数：4
相关论文
共 50 条
  • [21] Effects of tumor necrosis factor-alpha in rats is potentiated by corticosterone
    Raina, N
    Jeejeebhoy, KN
    FASEB JOURNAL, 1996, 10 (03): : 1639 - 1639
  • [22] EFFECTS OF HYPOXIA ON THE CYTOTOXICITY MEDIATED BY TUMOR-NECROSIS-FACTOR-ALPHA
    NALDINI, A
    CESARI, S
    BOCCI, V
    LYMPHOKINE AND CYTOKINE RESEARCH, 1994, 13 (04): : 233 - 237
  • [23] MECHANISMS THAT REGULATE THE PRODUCTION AND EFFECTS OF TUMOR NECROSIS FACTOR-ALPHA
    KUNKEL, SL
    REMICK, DG
    STRIETER, RM
    LARRICK, JW
    CRITICAL REVIEWS IN IMMUNOLOGY, 1989, 9 (02) : 93 - 117
  • [24] EFFECTS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) ON COLLAGEN ARTHRITIS
    BRAHN, E
    PEACOCK, DJ
    BANQUERIGO, ML
    LIU, DY
    LYMPHOKINE AND CYTOKINE RESEARCH, 1992, 11 (05): : 253 - 256
  • [25] INCREASED PLASMA TUMOR-NECROSIS-FACTOR-ALPHA CONCENTRATION IN ATOPIC-DERMATITIS
    SUMIMOTO, S
    KAWAI, M
    KASAJIMA, Y
    HAMAMOTO, T
    ARCHIVES OF DISEASE IN CHILDHOOD, 1992, 67 (03) : 277 - 279
  • [26] A STUDY OF THE SERUM CONCENTRATION OF TUMOR-NECROSIS-FACTOR-ALPHA IN THYROIDAL AND NONTHYROIDAL ILLNESSES
    CHOPRA, IJ
    SAKANE, S
    TECO, GNC
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (05): : 1113 - 1116
  • [27] Tumor necrosis factor alpha system and plasma adiponectin concentration in women with gestational diabetes
    Kinalski, M
    Telejko, B
    Kuzmicki, M
    Kretowski, A
    Kinalska, I
    HORMONE AND METABOLIC RESEARCH, 2005, 37 (07) : 450 - 454
  • [28] Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Sipkens, Jessica A.
    Krijnen, Paul A. J.
    Meischl, Christof
    Cillessen, Saskia A. G. M.
    Smulders, Yvo M.
    Smith, Desiree E. C.
    Giroth, Cindy P. E.
    Spreeuwenberg, Marieke D.
    Musters, Rene J. P.
    Muller, Alice
    Jakobs, Cornelis
    Roos, Dirk
    Stehouwer, Coen D. A.
    Rauwerda, Jan A.
    van Hinsbergh, Victor W. M.
    Niessen, Hans W. M.
    APOPTOSIS, 2007, 12 (08) : 1407 - 1418
  • [29] Concentration-dependent effects of hydrogen peroxide on Drosophila Kc167 cell proliferation, apoptosis, and necrosis
    Marcey, D
    Hannahs, G
    Johnson, D
    Denning, D
    Levi, S
    Gibney, B
    MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 101 - 101
  • [30] Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A. Sipkens
    Paul A. J. Krijnen
    Christof Meischl
    Saskia A. G. M. Cillessen
    Yvo M. Smulders
    Desirée E. C. Smith
    Cindy P. E. Giroth
    Marieke D. Spreeuwenberg
    René J. P. Musters
    Alice Muller
    Cornelis Jakobs
    Dirk Roos
    Coen D. A. Stehouwer
    Jan A. Rauwerda
    Victor W. M. van Hinsbergh
    Hans W. M. Niessen
    Apoptosis, 2007, 12 : 1407 - 1418
12345