Functions of HLA-G in the immune system

被引：32
|
作者：
Favier, B. [1 ]
LeMaoult, J. [1 ]
Carosella, E. D. [1 ]
机构：
[1] Inst Univ Hematol, Hop St Louis, Serv Rech Hemato Immunol, Direct Sci Vivant,Dept Rech Med,Commissariat Ener, F-75010 Paris, France
来源：
TISSUE ANTIGENS | 2007年 / 69卷
关键词：
HLA-G; immune inhibition; tolerance;
D O I：
10.1111/j.1399-0039.2006.763_6.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has tolerogenic functions and acts on cells of both innate and adaptive immunity. The molecular mechanism leading to tolerance involves the interaction between HLA-G and inhibitory receptors that are expressed at the surface of immune cells. In this review, we will briefly summarize the key advances on the relationships between HLA-G and the immune system and their consequences in pathology.
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页码：150 / 152
页数：3
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